Glucuronidated Metabolites of Bisphenols A and S Alter the Properties of Normal Urothelial and Bladder Cancer Cells

Bisphenol A (BPA) and bisphenol S (BPS) are synthetic chemicals used to produce plastics which can be released in food and water. Once ingested, BPA and BPS are metabolized by the liver, mainly as glucuronidated metabolites, and are excreted through urine. Since urine can be stored for many hours, t...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-11, Vol.23 (21), p.12859
Main Authors: Pellerin, Ève, Pellerin, Félix-Antoine, Chabaud, Stéphane, Pouliot, Frédéric, Pelletier, Martin, Bolduc, Stéphane
Format: Article
Language:English
Subjects:
Bioenergetics
Bisphenol A
Bladder cancer
Cell proliferation
Estrogens
Glycolysis
Metabolism
Metabolites
Mitochondria
Physiological effects
Physiology
Respiration
Urine
Urothelial cancer
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Summary:Bisphenol A (BPA) and bisphenol S (BPS) are synthetic chemicals used to produce plastics which can be released in food and water. Once ingested, BPA and BPS are metabolized by the liver, mainly as glucuronidated metabolites, and are excreted through urine. Since urine can be stored for many hours, the bladder is chronically exposed to BP metabolites, and studies have shown that these metabolites can remain active in the organism. Therefore, the effect of physiological concentrations of glucuronidated BPs was evaluated on the bioenergetics (glycolysis and mitochondrial respiration), migration and proliferation of normal urothelial cells, and non-invasive and invasive bladder cancer cells. The results demonstrated that an exposure of 72 h to glucuronidated BPA or BPS decreased the bioenergetics and activity of normal urothelial cells, while increasing these parameters for bladder cancer cells. These findings suggest that BP metabolites are not as inactive as initially believed, and their ubiquitous presence in the urine could promote bladder cancer progression.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232112859