The Association of Tumor Immune Microenvironment of the Primary Lesion with Time to Metastasis in Patients with Renal Cell Carcinoma: A Retrospective Analysis

Biological or immunological differences in primary lesions between synchronous and metachronous metastatic renal cell carcinoma (mRCC) have been reported. However, the association between the tumor immune microenvironment (TIME) of primary lesions and time to metastasis remains unknown. We investiga...

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Bibliographic Details
Published in:Cancers 2022-10, Vol.14 (21), p.5258
Main Authors: Fujita, Kazutoshi, Kimura, Go, Tsuzuki, Toyonori, Kato, Taigo, Banno, Eri, Kazama, Akira, Yamashita, Ryo, Matsushita, Yuto, Ishii, Daisuke, Fukawa, Tomoya, Nakagawa, Yuki, Fukuyama, Tamaki, Sano, Fumikazu, Kondo, Yukihiro, Uemura, Hirotsugu
Format: Article
Language:English
Subjects:
Carcinoma, Renal cell
CD8 antigen
Development and progression
Growth patterns
Immunogenicity
Kidney cancer
Lesions
Lymphocytes
Medical prognosis
Metastases
Metastasis
Microenvironments
Necrosis
PD-L1 protein
Phenotypes
Regression analysis
Renal cell carcinoma
Review boards
Tumors
Variables
Vascular endothelial growth factor
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Summary:Biological or immunological differences in primary lesions between synchronous and metachronous metastatic renal cell carcinoma (mRCC) have been reported. However, the association between the tumor immune microenvironment (TIME) of primary lesions and time to metastasis remains unknown. We investigated the differences in the TIME of primary lesions based on time intervals to metastasis, mainly between the synchronous group (SG; metastasis within 3 months) and metachronous group (MG; metastasis after 3 months), and its association with clinicopathological parameters in patients with mRCC. Overall, 568 patients treated first-line with vascular endothelial growth factor receptor inhibitors comprised the analysis population (SG: N = 307 [54.0%]; MG: N = 261 [46.0%]). SG had a higher proportion of patients with poor prognostic pathological feature tumors: WHO/ISUP grade 4, necrosis, lymphovascular invasion, infiltrative growth pattern, and sarcomatoid differentiation. Regarding the TIME, more immunogenic features were seen in SG than MG, with a higher PD-L1 positivity and a lower proportion of the desert phenotype. This is the first study to examine the differences in the TIME of primary lesions in patients with mRCC based on the time intervals to metastasis. The TIME of primary lesions could affect the time to metastasis.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14215258