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A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression
Cancer is a disease of aging, but most studies on cancer are in young but not aged animal models, and cancer clinical trials are rarely performed in older adults. Recognition of the connections between aging and cancer and improvement of treatment for elderly cancer patients has become one of the mo...
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| Published in: | Cancers 2022-10, Vol.14 (21), p.5185 |
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| cites | cdi_FETCH-LOGICAL-c488t-7863dd3ef8a9b65c873af2817e9be7cbf1b24e4f60cf18f63a55e7f967e943e93 |
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| container_title | Cancers |
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| creator | Zhang, Qiuyang Jazwinski, S Michal |
| description | Cancer is a disease of aging, but most studies on cancer are in young but not aged animal models, and cancer clinical trials are rarely performed in older adults. Recognition of the connections between aging and cancer and improvement of treatment for elderly cancer patients has become one of the most critical medical issues with the global increase in the elderly population. Mouse models are essential experimental tools for understanding the molecular mechanisms of complex processes and related gene pathways of biological aging. However, few mouse models can be used to understand the role of aging in cancer development and the underlying mechanisms. One of the hallmarks of aging is chronic inflammation, often called inflammaging. This is our rationale for examining the role of aging-related inflammation in prostate cancer, a major aging malignancy. We have now developed a novel method to generate age-related cancer models in mice to better understand how age impacts cancer initiation and progression in the natural aging process. We discuss its application to elucidate some of the contributing mechanisms. |
| doi_str_mv | 10.3390/cancers14215185 |
| format | article |
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Recognition of the connections between aging and cancer and improvement of treatment for elderly cancer patients has become one of the most critical medical issues with the global increase in the elderly population. Mouse models are essential experimental tools for understanding the molecular mechanisms of complex processes and related gene pathways of biological aging. However, few mouse models can be used to understand the role of aging in cancer development and the underlying mechanisms. One of the hallmarks of aging is chronic inflammation, often called inflammaging. This is our rationale for examining the role of aging-related inflammation in prostate cancer, a major aging malignancy. We have now developed a novel method to generate age-related cancer models in mice to better understand how age impacts cancer initiation and progression in the natural aging process. We discuss its application to elucidate some of the contributing mechanisms.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14215185</identifier><identifier>PMID: 36358603</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Aging ; Alzheimer's disease ; Animal models ; Arthritis ; Cancer ; Cardiovascular disease ; Clinical trials ; Communication ; Development and progression ; Diabetes ; Epidemiology ; Epigenetics ; Geriatrics ; Health aspects ; Helper cells ; Immune system ; Inflammation ; Inflammatory diseases ; Lymphocytes ; Lymphocytes T ; Malignancy ; Molecular modelling ; Older people ; Prostate ; Prostate cancer ; Senescence ; T cells ; Tumor necrosis factor-TNF ; Tumorigenesis ; Tumors ; Womens health</subject><ispartof>Cancers, 2022-10, Vol.14 (21), p.5185</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Recognition of the connections between aging and cancer and improvement of treatment for elderly cancer patients has become one of the most critical medical issues with the global increase in the elderly population. Mouse models are essential experimental tools for understanding the molecular mechanisms of complex processes and related gene pathways of biological aging. However, few mouse models can be used to understand the role of aging in cancer development and the underlying mechanisms. One of the hallmarks of aging is chronic inflammation, often called inflammaging. This is our rationale for examining the role of aging-related inflammation in prostate cancer, a major aging malignancy. We have now developed a novel method to generate age-related cancer models in mice to better understand how age impacts cancer initiation and progression in the natural aging process. We discuss its application to elucidate some of the contributing mechanisms.</description><subject>Age</subject><subject>Aging</subject><subject>Alzheimer's disease</subject><subject>Animal models</subject><subject>Arthritis</subject><subject>Cancer</subject><subject>Cardiovascular disease</subject><subject>Clinical trials</subject><subject>Communication</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Epidemiology</subject><subject>Epigenetics</subject><subject>Geriatrics</subject><subject>Health aspects</subject><subject>Helper cells</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Malignancy</subject><subject>Molecular modelling</subject><subject>Older people</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Senescence</subject><subject>T cells</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><subject>Womens health</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptkk1r3DAQhk1paUKac29F0EsvTizr05fCsiRtIElLmp6FLI-8CrKUSnYg_77a5oNNqHTQMHred5hhquojbo4I6Zpjo4OBlDFtMcOSvan220a0NecdfbsT71WHOd805RCCBRfvqz3CCZO8IftVXqHLeAce_ZqTnmG8R3NEF3EomdUI9RX4kh3Q-l8pZGNCJ34xbtCziwFFi-YNoKvoYRtfb7BAZ8F6PU16dGFELjxJf6Y4Jsi5yD5U76z2GQ4f34Pq9-nJ9fp7ff7j29l6dV4bKuVcC8nJMBCwUnc9Z0YKom0rsYCuB2F6i_uWArW8MRZLy4lmDITteAEogY4cVF8ffG-XfoLBQCg9enWb3KTTvYraqZc_wW3UGO9Ux5nAhBWDL48GKf5ZIM9qctmA9zpAXLJqRRljR4TEBf38Cr2JSwqlvS1FOaa42aFG7UG5YGOpa7amaiUoa0WL26ZQR_-hyh1gciYGsK7kXwiOHwQmxZwT2OcecaO2q6JerUpRfNodzTP_tBjkL760ubU</recordid><startdate>20221022</startdate><enddate>20221022</enddate><creator>Zhang, Qiuyang</creator><creator>Jazwinski, S Michal</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7346-5296</orcidid></search><sort><creationdate>20221022</creationdate><title>A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression</title><author>Zhang, Qiuyang ; Jazwinski, S Michal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-7863dd3ef8a9b65c873af2817e9be7cbf1b24e4f60cf18f63a55e7f967e943e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Aging</topic><topic>Alzheimer's disease</topic><topic>Animal models</topic><topic>Arthritis</topic><topic>Cancer</topic><topic>Cardiovascular disease</topic><topic>Clinical trials</topic><topic>Communication</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Epidemiology</topic><topic>Epigenetics</topic><topic>Geriatrics</topic><topic>Health aspects</topic><topic>Helper cells</topic><topic>Immune system</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Malignancy</topic><topic>Molecular modelling</topic><topic>Older people</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Senescence</topic><topic>T cells</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qiuyang</creatorcontrib><creatorcontrib>Jazwinski, S Michal</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Research Library</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qiuyang</au><au>Jazwinski, S Michal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2022-10-22</date><risdate>2022</risdate><volume>14</volume><issue>21</issue><spage>5185</spage><pages>5185-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Cancer is a disease of aging, but most studies on cancer are in young but not aged animal models, and cancer clinical trials are rarely performed in older adults. 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| ispartof | Cancers, 2022-10, Vol.14 (21), p.5185 |
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| subjects | Age Aging Alzheimer's disease Animal models Arthritis Cancer Cardiovascular disease Clinical trials Communication Development and progression Diabetes Epidemiology Epigenetics Geriatrics Health aspects Helper cells Immune system Inflammation Inflammatory diseases Lymphocytes Lymphocytes T Malignancy Molecular modelling Older people Prostate Prostate cancer Senescence T cells Tumor necrosis factor-TNF Tumorigenesis Tumors Womens health |
| title | A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression |
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