SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease

SLU7 (Splicing factor synergistic lethal with U5 snRNA 7) was first identified as a splicing factor necessary for the correct selection of 3' splice sites, strongly impacting on the diversity of gene transcripts in a cell. More recent studies have uncovered new and non-redundant roles of SLU7 a...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-11, Vol.23 (21), p.13411
Main Authors: Gárate-Rascón, María, Recalde, Miriam, Rojo, Carla, Fernández-Barrena, Maite G, Ávila, Matías A, Arechederra, María, Berasain, Carmen
Format: Article
Language:English
Subjects:
Alternative Splicing
Amino acids
Cancer
Cell cycle
Cytoplasm
Epigenesis, Genetic
Epigenetics
Gene expression
Gene regulation
Genomes
Humans
Kinases
Liver
Liver diseases
Localization
Pathophysiology
Phosphorylation
Physiology
Protein Stability
Proteins
Review
Ribonucleoproteins, Small Nuclear - genetics
RNA polymerase
RNA Splice Sites
RNA Splicing
RNA Splicing Factors - genetics
snRNA
Splicing
Splicing factors
Stability
Survival factor
Therapeutic targets
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Summary:SLU7 (Splicing factor synergistic lethal with U5 snRNA 7) was first identified as a splicing factor necessary for the correct selection of 3' splice sites, strongly impacting on the diversity of gene transcripts in a cell. More recent studies have uncovered new and non-redundant roles of SLU7 as an integrative hub of different levels of gene expression regulation, including epigenetic DNA remodeling, modulation of transcription and protein stability. Here we review those findings, the multiple factors and mechanisms implicated as well as the cellular functions affected. For instance, SLU7 is essential to secure liver differentiation, genome integrity acting at different levels and a correct cell cycle progression. Accordingly, the aberrant expression of SLU7 could be associated with human diseases including cancer, although strikingly, it is an essential survival factor for cancer cells. Finally, we discuss the implications of SLU7 in pathophysiology, with particular emphasis on the progression of liver disease and its possible role as a therapeutic target in human cancer.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232113411