Thermally Treated Berberine-Loaded SA/PVA/PEO Electrospun Microfiber Membranes for Antibacterial Wound Dressings

This study aimed to develop a safe and advanced antibacterial material of electrospun microfiber membranes (MFMs) for wound dressings. Combinations of several materials were investigated; thermal treatment and electrospinning techniques were used to form the best quality of MFMs to suit its end appl...

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Bibliographic Details
Published in:Polymers 2022-10, Vol.14 (21), p.4473
Main Authors: Zhang, Jishu, Li, Yonggang, Wu, Huawei, Wang, Chunhong, Salleh, Kushairi Mohd, Li, Hongchang, Zakaria, Sarani
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibacterial materials
Antibiotics
Bacteria
Calcium chloride
Crosslinked polymers
Crosslinking
Dissolution
Drug resistance
E coli
Electric fields
Electrospinning
Escherichia coli
Fractions
Fracture strength
Heat treatment
Load resistance
Materials selection
Mechanical properties
Membranes
Metals
Microfibers
Moisture content
Moisture effects
Molecular weight
Morphology
Permeability
Polyethylene oxide
Polymers
Polyvinyl alcohol
Power supply
Raw materials
Reagents
Side effects
Sodium alginate
Substrates
Synthetic products
Viscosity
Wound healing
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Summary:This study aimed to develop a safe and advanced antibacterial material of electrospun microfiber membranes (MFMs) for wound dressings. Combinations of several materials were investigated; thermal treatment and electrospinning techniques were used to form the best quality of MFMs to suit its end applications. By comparing the fiber morphology, diameter changes, and fracture strength, the suitable ratio of raw materials and thermal treatment were obtained before and after adding Trition X-100 as a surfactant for MFMs of sodium alginate/polyvinyl alcohol/polyethylene oxide (SA/PVA/PEO). The electrospinning solution was mixed with berberine as an antibacterial substance; meanwhile, calcium chloride (CaCl2) was used as the crosslinking agent. The antibacterial properties, water dissolution resistance, water content, and fracture strength were thoroughly investigated. The results showed that the antibacterial rates of MFMs with different mass fractions of berberine (0, 3, and 5 wt.%) to Escherichia coli (E. coli) were 14.7, 92.9, and 97.2%, respectively. The moisture content and fracture strength of MFMs containing 5 wt.% berberine were 72.0% and 7.8 MPa, respectively. In addition, the produced MFMs embodied great water dissolution resistance. Berberine-loaded SA/PVA/PEO MFMs could potentially serve as an antibacterial wound dressing substrate with low cost and small side effects.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym14214473