Intermediate monocytes expansion and homing markers expression in COVID-19 patients associate with kidney dysfunction

• Published in: Clinical and experimental medicine 2023-08, Vol.23 (4), p.1235-1242
• Main Authors: Dentone, Chiara, Fenoglio, Daniela, Parodi, Alessia, Altosole, Tiziana, Di Biagio, Antonio, Bozzano, Federica, Nasi, Giorgia, Vena, Antonio, Fabbi, Marina, Ferrera, Francesca, Bruzzone, Bianca, Giacomini, Mauro, Giacobbe, Daniele Roberto, Pelosi, Paolo, De Maria, Andrea, Bassetti, Matteo, De Palma, Raffaele, Filaci, Gilberto
• Format: Article
• Language: English
• Subjects: Chemokine receptors; Clinical Practice; COVID-19; Hematology; HIV; Human immunodeficiency virus; Inflammation; Internal Medicine; Kidney diseases; Medicine; Medicine & Public Health; Monocyte chemoattractant protein 1; Monocytes; Oncology; Original; Original Article; Severe acute respiratory syndrome coronavirus 2
• ISSN: 1591-9528; 1591-8890; 1591-9528
• DOI: 10.1007/s10238-022-00927-9

Patients with severe SARS-CoV-2 infection have an overwhelming inflammatory response characterized by remarkable organs monocyte infiltration. We performed an immunophenotypic analysis on circulating monocytes in 19 COVID-19 patients in comparison with 11 naïve HIV-1 patients and 10 healthy subjects. Reduced frequency of classical monocytes and increased frequency of intermediate monocytes characterized COVID-19 patients with respect to both HIV naïve patients and healthy subjects. Intensity of C–C motif chemokine receptor 2 (CCR2) monocyte expression highly correlated with parameters of kidney dysfunction. Our data indicate that highly activated monocytes of COVID-19 patients may be pathogenically associated with the development of renal disease.