Prevalence of undiagnosed hepatitis B virus infection in patients with COVID-19A single center retrospective study

At its onset, the coronavirus disease 2019 (COVID-19) pandemic brought significant challenges to healthcare systems, changing the focus of medical care on acute illness. Disruptions in medical service provision have impacted the field of viral hepatitis, with screening programs paused throughout muc...

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Published in:Medicine (Baltimore) 2022-11, Vol.101 (45), p.e31385-e31385
Main Authors: Săndulescu, Oana, Streinu-Cercel, Anca, Miron, Victor Daniel, Apostolescu, Cătălin Gabriel, Nițescu, Maria, Drăgănescu, Anca Cristina, Streinu-Cercel, Adrian
Format: Article
Language:English
Subjects:
Acute Disease
Adult
COVID-19 - diagnosis
COVID-19 - epidemiology
Female
Hepatitis B - diagnosis
Hepatitis B - epidemiology
Hepatitis B - prevention & control
Hepatitis B Antibodies
Hepatitis B virus
Humans
Male
Middle Aged
Observational Study
Pandemics
Prevalence
Retrospective Studies
Thrombocytopenia - epidemiology
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Summary:At its onset, the coronavirus disease 2019 (COVID-19) pandemic brought significant challenges to healthcare systems, changing the focus of medical care on acute illness. Disruptions in medical service provision have impacted the field of viral hepatitis, with screening programs paused throughout much of 2020 and 2021. We performed a retrospective study on consecutive outpatients with COVID-19 during the second and third wave of COVID-19 in Romania, from November 2020 to April 2021, aiming to characterize the prevalence of undiagnosed hepatitis B virus (HBV) infection among patients presenting with acute illness. Overall, 522 patients had available records during the study timespan. Their mean ± standard deviation age was 51 ± 13 years; 274 (52.5%) were male. We identified 16 (3.1%) cases of active HBV infection; only six of these patients were aware of their HBV status, and 3 of the newly diagnosed cases were identified as candidates for HBV treatment. A total of 96 patients (18.4%) had serological markers suggestive for prior HBV vaccination. A large proportion of patients (n = 120, 23.0%) had positive HBV core antibodies; among these, 90 (17.2%) had cleared a previous HBV infection (being positive for HBV surface antibodies and HBV core antibodies). We identified the following parameters that were significantly more frequent in patients with a history of HBV infectionolder age ( P  
ISSN:1536-5964
0025-7974
1536-5964
DOI:10.1097/MD.0000000000031385