Prognostic Value of Arterial Lactate Metabolic Clearance Rate in Moderate and Severe Acute Pancreatitis

Purpose. High lactate levels at hospital admission are significantly associated with poor prognosis in acute pancreatitis patients. Early high lactate clearance is a vital marker for predicting persistent organ failure and mortality in critical illness; however, its value in acute pancreatitis remai...

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Bibliographic Details
Published in:Disease markers 2022-11, Vol.2022, p.1-8
Main Authors: Zeng, Jiji, Wan, Jianhua, He, Wenhua, Zhu, Yong, Zeng, Hao, Liu, Pi, Gong, Min, Liu, Fen, Shao, Qiang, Xia, Liang, Zhu, Yin, Chen, Youxiang, Lu, Nonghua
Format: Article
Language:English
Subjects:
Abdomen
Biomarkers
Blood
Death
Failure rates
Lactic acid
Length of stay
Medical prognosis
Metabolism
Mortality
Multiple organ dysfunction syndrome
Multivariate analysis
Necrosis
Pancreatitis
Patients
Regression analysis
Sepsis
Statistical analysis
Urea
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Summary:Purpose. High lactate levels at hospital admission are significantly associated with poor prognosis in acute pancreatitis patients. Early high lactate clearance is a vital marker for predicting persistent organ failure and mortality in critical illness; however, its value in acute pancreatitis remains unclear. Method. Data were collected from patients who were diagnosed with moderately severe acute pancreatitis and severe acute pancreatitis from January 2017 to December 2020. Initial lactate (within 2 hours after admission) and repeat lactate at 24 hours after admission were measured to determine lactate clearance. Low clearance was defined as a reduction in repeat lactate of less than 30% compared to the first measurement. High clearance was defined as a repeat lactate decrease ≥30% of the first measurement or both first and second lactate levels
ISSN:0278-0240
1875-8630
DOI:10.1155/2022/9233199