Myeloid-derived suppressor cells: Cancer, autoimmune diseases, and more

Although cancer immunotherapy using immune checkpoint inhibitors (ICIs) has been recognized as one of the major treatment modalities for malignant diseases, the clinical outcome is not uniform in all cancer patients. Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of im...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget 2022-11, Vol.13, p.1273-1285
Main Authors: Shibata, Masahiko, Nanno, Kotaro, Yoshimori, Daigo, Nakajima, Takahiro, Takada, Makoto, Yazawa, Takashi, Mimura, Kousaku, Inoue, Norio, Watanabe, Takafumi, Tachibana, Kazunoshin, Muto, Satoshi, Momma, Tomoyuki, Suzuki, Yoshiyuki, Kono, Koji, Endo, Shungo, Takenoshita, Seiichi
Format: Article
Language:English
Subjects:
Autoimmune Diseases
Female
Humans
Immunotherapy
Infant, Newborn
Myeloid Cells
Myeloid-Derived Suppressor Cells
Neoplasms - pathology
Pregnancy
Review
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although cancer immunotherapy using immune checkpoint inhibitors (ICIs) has been recognized as one of the major treatment modalities for malignant diseases, the clinical outcome is not uniform in all cancer patients. Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells that possess various strong immunosuppressive activities involving multiple immunocompetent cells that are significantly accumulated in patients who did not respond well to cancer immunotherapies. We reviewed the perspective of MDSCs with emerging evidence in this review. Many studies on MDSCs were performed in malignant diseases. Substantial studies on the participation of MDSCs on non-malignant diseases such as chronic infection and autoimmune diseases, and physiological roles in obesity, aging, pregnancy and neonates have yet to be reported. With the growing understanding of the roles of MDSCs, variable therapeutic strategies and agents targeting MDSCs are being investigated, some of which have been used in clinical trials. More studies are required in order to develop more effective strategies against MDSCs.
ISSN:1949-2553
DOI:10.18632/oncotarget.28303