The roles of MTHFR (C677T, A1298C) and MGP (G-7A, T-138C) gene variations in development of diabetic nephropathy in patients with type 2 diabetes mellitus

Background The goal of this study is to determine the role of MTHFR (C677T, A1298C) and MGP (G-7A, T-138C) gene variations in DN development. Methods There were 61 DN patients and 55 healthy controls in this study. The genotype distributions of these gene variations were determined using PCR and RFL...

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Bibliographic Details
Published in:Journal of diabetes and metabolic disorders 2022-12, Vol.21 (2), p.1317-1326
Main Authors: Ay, Arzu, Alkanli, Nevra, Kurt, Idris, Ustundag, Sedat, Sipahi, Tammam, Sut, Necdet
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Diabetes
Diabetic nephropathies
Endocrinology
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Genetic research
Medicine
Medicine & Public Health
Metabolic Diseases
Research Article
Type 2 diabetes
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Summary:Background The goal of this study is to determine the role of MTHFR (C677T, A1298C) and MGP (G-7A, T-138C) gene variations in DN development. Methods There were 61 DN patients and 55 healthy controls in this study. The genotype distributions of these gene variations were determined using PCR and RFLP methods. Results According to our study, there was no significant relationship between these gene variations and DN ( p  > 0.05). The allele frequencies of the MTHFR C677T gene variation in the control group were found significantly different from the Hardy-Weinberg distribution ( p  
ISSN:2251-6581
2251-6581
DOI:10.1007/s40200-022-01061-9