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Infectivity of Plasmodium berghei sporozoites delivered by intravenous inoculation versus mosquito bite: implications for sporozoite vaccine trials

Plasmodium berghei sporozoites delivered by mosquito bite were more infectious to outbred CD-1 mice than were sporozoites delivered by intravenous inoculation. The route of challenge also affected vaccine efficacy. In view of these findings and the fact that mosquito bites are the natural mode of sp...

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Bibliographic Details
Published in:Infection and immunity 1999-08, Vol.67 (8), p.4285-4289
Main Authors: Vaughan, J.A, Scheller, L.F, Wirtz, R.A, Azad, A.F
Format: Article
Language:English
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Summary:Plasmodium berghei sporozoites delivered by mosquito bite were more infectious to outbred CD-1 mice than were sporozoites delivered by intravenous inoculation. The route of challenge also affected vaccine efficacy. In view of these findings and the fact that mosquito bites are the natural mode of sporozoite delivery, infectious mosquito bites should be considered the challenge protocol of choice for sporozoite vaccine efficacy trials.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.67.8.4285-4289.1999