Ethnic differences between Asians and non-Asians in clustering-based phenotype classification of adult-onset diabetes mellitus: A systematic narrative review

Several international studies have stratified people with diabetes into phenotypical clusters. However, there has not been a systematic examination of the variation in these clusters across ethnic groups. For example, some clusters appear more frequent among Asians and may have lower weight, age at...

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Bibliographic Details
Published in:Primary care diabetes 2022-12, Vol.16 (6), p.853-856
Main Authors: Varghese, Jithin Sam, Narayan, K.M. Venkat
Format: Article
Language:English
Subjects:
Asian
Cluster analysis
Diabetes phenotypes
Subgroups
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Summary:Several international studies have stratified people with diabetes into phenotypical clusters. However, there has not been a systematic examination of the variation in these clusters across ethnic groups. For example, some clusters appear more frequent among Asians and may have lower weight, age at diagnosis and poorer beta cell function. •There has not been a systematic examination of variation in phenotypical clusters by ethnicity.•Insulin deficiency cluster was more frequent than insulin resistant cluster among Asians.•Clusters with combined insulin deficiency and resistance were reported in Indian and Chinese populations.•Clusters have earlier age at diagnosis, lower BMI and poorer beta cell function among Asians, relative to Non-Asians.
ISSN:1751-9918
1878-0210
DOI:10.1016/j.pcd.2022.09.007