Effects of Methylsulfonylmethane on UVB-induced Skin Damage: An Experimental Study in a Mouse Model

• Published in: In vivo (Athens) 2022-11, Vol.36 (6), p.2714-2721
• Main Authors: Chu, Seung Gyun, Chang, Yong June, Ryu, Jeong Yeop, Lee, Joon Seok, Choi, Kang Young, Chung, Ho Yun, Cho, Byung Chae, Yang, Jung Dug
• Format: Article
• Language: English
• Subjects: Animals; Mice; Mice, Hairless; Skin; Skin Aging; Tretinoin - pharmacology; Ultraviolet Rays - adverse effects
• ISSN: 0258-851X; 1791-7549
• DOI: 10.21873/invivo.13007

The skin protects the body from ultraviolet rays and other external factors. Various studies have been conducted to identify methods to prevent skin aging and damage. To investigate the protective effects of methylsulfonylmethane (MSM), in this study, a hairless mouse model was used. Mice divided into Groups B, C, and D were subjected to UVB irradiation for six weeks, and Group A was considered the control. Retinoic acid is a substance that has been proven to have anti-aging properties. Group C was injected with MSM, group D was injected with retinoic acid, and groups A and B were injected with saline. At the end of the experiment, the degree of senescence was confirmed through visual evaluation, histopathological analysis, immunohistochemistry, and elasticity measurement using SEM. After the end of the experiment, the wrinkle score was 0.4, 2.5, 1.8, 1.5 for Groups A, B, C, and D, respectively. Epidermal thickness was 40 μm, 70 μm, 60 μm, 55 μm in Groups A, B, C, and D, respectively. Group C showed less collagen confirmation loss and more angiogenesis and elastin precursor production. Elastic fiber linearity was 0.901±0.02, 0.551±0.04, 0.751±0.04, 0.822±0.03 for Groups A, B, C, and D, respectively. Injection of MSM in mice subjected to UVB-induced skin damage reduces the wrinkle score and protects against photoaging.