Friend turned foe: TREM2 agonist in battles against tau

In this important study, Jain et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220654) find that chronic TREM2 activation by AL002a antibody exacerbates the seeding and spread of pathological tau, enhances the disease-associated microglial signature, and increases neurite dystrophy in 5xFAD m...

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Bibliographic Details
Published in:The Journal of experimental medicine 2023-01, Vol.220 (1)
Main Authors: Carling, Gillian, Luo, Wenjie, Gan, Li
Format: Article
Language:English
Subjects:
Alzheimer Disease - pathology
Animals
Friends
Graft vs Host Disease - pathology
Humans
Insights
Membrane Glycoproteins
Mice
Microglia - pathology
Receptors, Immunologic
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Summary:In this important study, Jain et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220654) find that chronic TREM2 activation by AL002a antibody exacerbates the seeding and spread of pathological tau, enhances the disease-associated microglial signature, and increases neurite dystrophy in 5xFAD mice seeded with Alzheimer's disease tau.
ISSN:0022-1007
1540-9538
1540-9538
DOI:10.1084/jem.20221850