Inferring bona fide Differentially Expressed Genes and Their Variants Associated with Vitamin K Deficiency Using a Systems Genetics Approach

Systems genetics is key for integrating a large number of variants associated with diseases. Vitamin K (VK) is one of the scarcely studied disease conditions. In this work, we ascertained the differentially expressed genes (DEGs) and variants associated with individual subpopulations of VK disease p...

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Bibliographic Details
Published in:Genes 2022-11, Vol.13 (11), p.2078
Main Authors: Rajagopal, Shalini, Sharma, Akanksha, Simlot, Anita, Mathur, Praveen, Mehta, Sudhir, Mehta, Sumita, Naravula, Jalaja, Medicherla, Krishna Mohan, Kumar, Anil, Kanga, Uma, Suravajhala, Renuka, Bhandari, Ramji Kumar, Nair, Bipin G, Kishor, P B Kavi, Suravajhala, Prashanth
Format: Article
Language:English
Subjects:
Archives & records
Biomarkers
Blood diseases
Datasets
Gene expression
Genomes
Genomics
Hemoglobin
Humans
Male
Mutation
Myocardial infarction
Phenotypes
Prostate cancer
Prostatic Neoplasms
Proteins
Renal failure
RNA, Long Noncoding - genetics
Subpopulations
Vitamin deficiency
Vitamin K
Vitamin K Deficiency
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Summary:Systems genetics is key for integrating a large number of variants associated with diseases. Vitamin K (VK) is one of the scarcely studied disease conditions. In this work, we ascertained the differentially expressed genes (DEGs) and variants associated with individual subpopulations of VK disease phenotypes, ., myocardial infarction, renal failure and prostate cancer. We sought to ask whether or not any DEGs harbor pathogenic variants common in these conditions, attempt to bridge the gap in finding characteristic biomarkers and discuss the role of long noncoding RNAs (lncRNAs) in the biogenesis of VK deficiencies.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes13112078