Polymorphic Variants of AGT, ABCA1 , and CYBA Genes Influence the Survival of Patients with Coronary Artery Disease: A Prospective Cohort Study

• Published in: Genes 2022-11, Vol.13 (11), p.2148
• Main Authors: Balcerzyk-Matić, Anna, Nowak, Tomasz, Mizia-Stec, Katarzyna, Iwanicka, Joanna, Iwanicki, Tomasz, Bańka, Paweł, Jarosz, Alicja, Filipecki, Artur, Żak, Iwona, Krauze, Jolanta, Niemiec, Paweł
• Format: Article
• Language: English
• Subjects: ABCA1 protein; Alleles; Angiotensinogen - genetics; ATP Binding Cassette Transporter 1 - genetics; ATP-binding protein; Body mass index; Cardiovascular disease; Cohort analysis; Coronary artery disease; Coronary Artery Disease - genetics; Coronary vessels; Death; Diabetes; Disease Susceptibility; Gene polymorphism; Genes; Genetic diversity; Genetic factors; Genomes; Genotype; Health risk assessment; Heart diseases; Heterozygotes; Homozygotes; Humans; Hyperlipidemia; Hypertension; Multivariate analysis; NADPH Oxidases - genetics; NADPH Oxidases - metabolism; Patients; Phenotypes; Polymorphism, Genetic; Prospective Studies; Risk factors; Smoking; Software; Survival; Vein & artery diseases
• ISSN: 2073-4425; 2073-4425
• DOI: 10.3390/genes13112148

Genetic factors can influence the risk of coronary artery disease (CAD) and the survival of patients. Our previous research led to the identification of genetic variants predisposing to CAD in the Polish population. Since many of them affect the clinical phenotype of the disease, the aim of this study was searching for genetic factors potentially influencing survival in patients with CAD. The study included 276 patients hospitalized due to coronary artery disease. The database of medical history and genotypic results of 29 polymorphisms were used. The endpoint was defined as death from cardiovascular causes. Survival was defined as the period from angiographic confirmation of CAD to death from cardiovascular causes. Three of all the analyzed genes were associated with survival. In the case of the (rs699) and (rs2230806) genes polymorphisms, the risk of death was higher in GG homozygotes compared to the A allele carriers in the 10-year period. In the case of the (rs72811418) gene polymorphism, the effect on mortality was shown in both 5- and 10-year periods. The TA heterozygotes were predisposed to a higher risk of death than the TT homozygotes. Concluding, the , and genes polymorphisms influence the risk of death in patients with CAD.