Macrophages at the Crossroad of Meta-Inflammation and Inflammaging

Macrophages are central players in systemic inflammation associated with obesity and aging, termed meta-inflammation and inflammaging. Activities of macrophages elicited by the two chronic conditions display shared and distinct patterns mechanistically, resulting in multifaceted actions for their pa...

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Bibliographic Details
Published in:Genes 2022-11, Vol.13 (11), p.2074
Main Authors: Qu, Lili, Matz, Alyssa J, Karlinsey, Keaton, Cao, Ziming, Vella, Anthony T, Zhou, Beiyan
Format: Article
Language:English
Subjects:
Adults
Age
Aging
Antigens
Body fat
Brain
Cytokines
Disease
Genetic aspects
Glucose
Health aspects
Inflammation
Insulin resistance
Liver
Macrophages
Metabolism
Molecular modelling
Mortality
Musculoskeletal system
Obesity
Older people
Pathogens
Physiology
Population
Review
Tumor necrosis factor-TNF
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Summary:Macrophages are central players in systemic inflammation associated with obesity and aging, termed meta-inflammation and inflammaging. Activities of macrophages elicited by the two chronic conditions display shared and distinct patterns mechanistically, resulting in multifaceted actions for their pathogenic roles. Drastically expanded tissue macrophage populations under obesity and aging stress attribute to both enhanced recruitment and local expansion. Importantly, molecular networks governing the multifaceted actions of macrophages are directly altered by environmental cues and subsequently contribute to metabolic reprogramming, resulting in meta-inflammation in obesity or inflammaging in aging. In this review, we will summarize how meta-inflammation and inflammaging affect macrophages and the molecular mechanisms involved in these processes.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes13112074