BET-ting on histone proteomics in schizophrenia

In a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation ‘reader...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2022-10, Vol.45 (10), p.716-717
Main Author: Kundakovic, Marija
Format: Article
Language:English
Subjects:
BRD4
histone acetylation
histone variants
iPSC-derived neurons
postmortem brain
schizophrenia
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Summary:In a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation ‘reader’, and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2022.06.001