Adhesive Bioinspired Coating for Enhancing Glass-Ceramics Scaffolds Bioactivity

Bioceramic scaffolds, composed of a biphasic composite containing bioactive glass and hydroxyapatite, were prepared in this work to overcome the intrinsic limits of the two components taken separately (in particular, their specific reactivities and dissolution rates, which should be tunable as a fun...

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Bibliographic Details
Published in:Materials 2022-11, Vol.15 (22), p.8080
Main Authors: Bellucci, Devis, Scalzone, Annachiara, Ferreira, Ana Marina, Cannillo, Valeria, Gentile, Piergiorgio
Format: Article
Language:English
Subjects:
Adhesives
Alkaline phosphatase
Bioceramics
Bioglass
Biological activity
Biomimetics
Bones
Cell adhesion & migration
Ceramic materials
Ceramics
Coating
Coatings
Contact angle
Dopamine
Extracellular matrix
Gelatin
Glass ceramics
Hydroxyapatite
Polyethylene
Polymers
Porosity
Scaffolds
Sintering
Stem cells
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Summary:Bioceramic scaffolds, composed of a biphasic composite containing bioactive glass and hydroxyapatite, were prepared in this work to overcome the intrinsic limits of the two components taken separately (in particular, their specific reactivities and dissolution rates, which should be tunable as a function of the given clinical requirements). To mimic the biological environment and tune the different stages of cellular response, a coating with gelatin and chondroitin sulphate via Layer-by-Layer (LbL) assembly was presented and discussed. The resulting functionalized scaffolds were affected by the coating in terms of microstructure and porosity. In addition, the LbL coating significantly enhanced the seeded cell behaviour, with high adhesion, proliferation and osteogenic activity, as revealed by the alkaline phosphatase activity and overexpression of osteopontin and osteocalcin.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma15228080