Pain management for necrotizing enterocolitis: getting the balance right

• Published in: Pediatric research 2022-11, Vol.92 (5), p.1423-1431
• Main Authors: ten Barge, Judith A., Vermeulen, Marijn J., Simons, Sinno H. P., van den Bosch, Gerbrich E.
• Format: Article
• Language: English
• Subjects: Acute Disease; Analgesics; Clinical; Clinical Research Article; Enterocolitis, Necrotizing - complications; Enterocolitis, Necrotizing - diagnosis; Enterocolitis, Necrotizing - drug therapy; Female; Fetal Diseases; Gastrointestinal diseases; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infant, Very Low Birth Weight; Medicine; Medicine & Public Health; Necrosis; Pain; Pain Management; Pediatric Surgery; Pediatrics; Retrospective Studies
• ISSN: 0031-3998; 1530-0447
• DOI: 10.1038/s41390-022-01968-2

Background Adequate pain management for preterm born neonates suffering from the extremely painful disease necrotizing enterocolitis (NEC) is essential, since neonatal exposure to pain is related to negative short-term and long-term consequences. The aim of this study was to describe the current pain management and its effectiveness in NEC patients. Methods In this single-center, retrospective study, neonates (gestational age < 32 weeks and/or birth weight < 1500 g) with NEC Bell’s stage II or III were included. Information on pain (based on COMFORTneo and NRS scores) and analgesic therapy was collected and analyzed for the acute disease period. Results Of 79 patients included, 74 (94%) received intravenous analgesic therapy: most commonly morphine, fentanyl, and acetaminophen. The median COMFORTneo score was 11 (IQR 10–11), however, 49 patients had at least one COMFORTneo score ≥ 14 indicating pain. Nineteen patients had persistent high pain scores ≥ 14 with a median duration of 7.2 h (IQR 2.8–14.0). Conclusions This study showed that despite analgesic therapy, most NEC patients showed signs of pain, and in some, pain persisted for several hours. It suggests that current analgesic therapy frequently failed to prevent pain and existing pain was often insufficiently treated. This supports the urgent need for individualized pain management guidelines for NEC patients. Impact This study is unique in reporting on pain management in neonates suffering from necrotizing enterocolitis (NEC) during the full acute disease period. Despite analgesic therapy, the majority of NEC patients experience pain, and in some patients, pain persists for several hours. These findings highlight the need for improvement of neonatal pain management in NEC patients, including better pain monitoring and guidelines for individualized analgesic therapy. Improved pain management guidelines may help to prevent short-term and long-term consequences of neonatal exposure to pain, as well as excessive exposure to opioids.