Regulatory T-lymphocyte subsets in children with chronic immune thrombocytopenia after high-dose of dexamethasone

• Published in: Pediatric research 2022-11, Vol.92 (5), p.1432-1436
• Main Authors: Elsayh, Khalid Ibrahim, Saad, Khaled, Osman, Naglaa Samy, Mahmoud, Khaled Hashim, Ahmad, Faisal A., Khalaf, Shaimaa M., Sayed, Noha G., Zahran, Zeinab Albadry M., Ghandour, Aliaa M. A., Elhoufey, Amira A., Bedir, Tamer, Zahran, Asmaa
• Format: Article
• Language: English
• Subjects: Autoimmunity; Child; Clinical; Clinical Research Article; Dexamethasone - therapeutic use; Humans; Medicine; Medicine & Public Health; Pediatric Surgery; Pediatrics; Purpura, Thrombocytopenic, Idiopathic - chemically induced; Purpura, Thrombocytopenic, Idiopathic - drug therapy; Steroids; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Thrombocytopenia
• ISSN: 0031-3998; 1530-0447
• DOI: 10.1038/s41390-022-01978-0

Background Immune thrombocytopenia (ITP) is an acquired autoimmune disease. This study’s objective was to estimate the variations in the population of CD4 + CD25 +High FoxP3 + cells (CD4 + regulatory T-lymphocytes; Tregs) in previously untreated children with chronic ITP managed in Assiut University Hospitals, as well as to evaluate the efficacy of high-dose dexamethasone (HD-DXM) in these patients. Methods In this study, we investigated the frequencies of T-lymphocyte subsets in 27 untreated children with chronic ITP. Results Prior to treatment, the percentages of CD4 + CD25 High cells and Tregs were significantly lower in the chronic ITP group compared to the control group ( p  = 0.018 and p