Integration of Lipidomics and Transcriptomics Reveals the Efficacy and Mechanism of Qige Decoction on NAFLD

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing as obesity and diabetes become more common. There are no drugs approved for NAFLD yet. Qige decoction (QGD), a traditional Chinese medicine (TCM) formula, is used for NAFLD and hyperlipidemia treatment in TCM and has shown hypo...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2022-11, Vol.2022, p.1-13
Main Authors: Fan, Simin, Zhou, Zunming, Ye, Jintong, Li, Yanfang, Huang, Keer, Ke, Xuehong
Format: Article
Language:English
Subjects:
Biosynthesis
Chinese medicine
Cholesterol
Diabetes mellitus
Disease
Drug dosages
Fatty acids
Fatty liver
Gene expression
Glucose
High fat diet
Hyperlipidemia
Insulin
Insulin resistance
Laboratory animals
Lipid metabolism
Lipids
Liver
Liver diseases
Low density lipoprotein
Metabolism
Metabolites
Molecular modelling
Pharmaceutical industry
Steatosis
Traditional Chinese medicine
Transcriptomes
Transcriptomics
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Summary:The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing as obesity and diabetes become more common. There are no drugs approved for NAFLD yet. Qige decoction (QGD), a traditional Chinese medicine (TCM) formula, is used for NAFLD and hyperlipidemia treatment in TCM and has shown hypolipidemic and hepatoprotective effects. This study tried to interpret the pharmacology and molecular mechanisms of QGD in NAFLD rats. Firstly, the therapeutic effects of QGD on high-fat diet (HFD)-induced NAFLD rats were evaluated. Then, integration of lipidomics and transcriptomics was conducted to explore the possible pathways and targets of QGD against NAFLD. QGD at low dosage (QGL) administration reduced serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/9739032