The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial

Background and objectives Constipation is one of the most common gastrointestinal conditions, particularly among older individuals. This study aimed to evaluate the efficacy and safety of selected multistrain probiotics on functional constipation and laboratory blood parameters in the elderly living...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical nutrition 2022-12, Vol.76 (12), p.1675-1681
Main Authors: Šola, Katarina Fehir, Vladimir-Knežević, Sanda, Hrabač, Pero, Mucalo, Iva, Saso, Luciano, Verbanac, Donatella
Format: Article
Language:English
Subjects:
692/308/2779/777
692/700/1518
692/700/459/1994
Aged
Bifidobacterium animalis
Blood
Clinical Nutrition
Constipation
Constipation - drug therapy
Constipation - microbiology
Dietary supplements
Double-Blind Method
Epidemiology
Feces - microbiology
Female
Humans
Internal Medicine
Laboratories
Lactobacilli
Lactobacillus acidophilus
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Older people
Parameters
Placebos
Probiotics
Probiotics - therapeutic use
Public Health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c474t-41debea0f43c93e3c3a66fddcb031976e1b4262fb20593d4342f078e76749ee33
cites cdi_FETCH-LOGICAL-c474t-41debea0f43c93e3c3a66fddcb031976e1b4262fb20593d4342f078e76749ee33
container_end_page 1681
container_issue 12
container_start_page 1675
container_title European journal of clinical nutrition
container_volume 76
creator Šola, Katarina Fehir
Vladimir-Knežević, Sanda
Hrabač, Pero
Mucalo, Iva
Saso, Luciano
Verbanac, Donatella
description Background and objectives Constipation is one of the most common gastrointestinal conditions, particularly among older individuals. This study aimed to evaluate the efficacy and safety of selected multistrain probiotics on functional constipation and laboratory blood parameters in the elderly living in a nursing home. Subjects and methods Sixty participants (42 females and 18 males) aged 77.9 ± 8.84 years with functional constipation, who met the eligibility criteria, completed the study. In a double-blind, placebo-controlled, parallel design, each participant was randomized to receive either the selected probiotic mixture ( N  = 28) or placebo ( N  = 32) for 12 weeks as an adjunct to their usual diet and medications. The liquid probiotic formulation containing Bifidobacterium animalis subsp. lactis BLC1, Lactobacillus acidophilus LA3 and Lactobacillus casei BGP93 was tested for the first time. Results Supplementation of selected probiotics resulted in a slight but nonsignificant increase in cumulative stool frequency compared with placebo. However, after the 71st day of the treatment, the cumulative number of stools was significantly higher in the probiotic group ( P  
doi_str_mv 10.1038/s41430-022-01189-0
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9708599</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2741155364</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-41debea0f43c93e3c3a66fddcb031976e1b4262fb20593d4342f078e76749ee33</originalsourceid><addsrcrecordid>eNp9kUtv1TAQhS0EopfCH2CBLLFhExg_El-zQEIVL6kSm7K2HGfcunLii-0glV-Pwy3lsWDlsc43x-M5hDxl8JKB2L8qkkkBHXDeAWN73cE9smNSDV0_SLhPdqB72QkAdUIelXIN0ETFH5IT0WuuepA7Ml9cIUXv0VWaPJ3XWEOp2YaFHnIaQ6rBFZoW6tfF1ZAWG6lLS6nhYLcrbWDdLOKEOd68ppZmu0xpDt9x2siaU4ytrDnY-Jg88DYWfHJ7npIv799dnH3szj9_-HT29rxzUsnaSTbhiBa8FE4LFE7YYfDT5EYQTKsB2Sj5wP3IoddikkJyD2qPalBSIwpxSt4cfQ_rOOPksI1hoznkMNt8Y5IN5m9lCVfmMn0zWsG-17oZvLg1yOnriqWaORSHMdoF01oMH3RDlWQb-vwf9Dqtue2pUQ1gfS8G2Sh-pFxOpWT0d8MwMFua5pimaWman2kaaE3P_vzGXcuv-BogjkBp0nKJ-ffb_7H9Acm5rRE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2741155364</pqid></control><display><type>article</type><title>The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial</title><source>Nexis Advance UK (Federated Access)</source><source>Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List</source><creator>Šola, Katarina Fehir ; Vladimir-Knežević, Sanda ; Hrabač, Pero ; Mucalo, Iva ; Saso, Luciano ; Verbanac, Donatella</creator><creatorcontrib>Šola, Katarina Fehir ; Vladimir-Knežević, Sanda ; Hrabač, Pero ; Mucalo, Iva ; Saso, Luciano ; Verbanac, Donatella</creatorcontrib><description>Background and objectives Constipation is one of the most common gastrointestinal conditions, particularly among older individuals. This study aimed to evaluate the efficacy and safety of selected multistrain probiotics on functional constipation and laboratory blood parameters in the elderly living in a nursing home. Subjects and methods Sixty participants (42 females and 18 males) aged 77.9 ± 8.84 years with functional constipation, who met the eligibility criteria, completed the study. In a double-blind, placebo-controlled, parallel design, each participant was randomized to receive either the selected probiotic mixture ( N  = 28) or placebo ( N  = 32) for 12 weeks as an adjunct to their usual diet and medications. The liquid probiotic formulation containing Bifidobacterium animalis subsp. lactis BLC1, Lactobacillus acidophilus LA3 and Lactobacillus casei BGP93 was tested for the first time. Results Supplementation of selected probiotics resulted in a slight but nonsignificant increase in cumulative stool frequency compared with placebo. However, after the 71st day of the treatment, the cumulative number of stools was significantly higher in the probiotic group ( P  &lt; 0.05) when the influence of laxative was excluded. The trend towards an increase in the difference between the two groups, which began 1 week after the probiotic intervention, pointed out to their prolonged effect. There were no significant dependent or independent effects of treatment and time on most of the 27 laboratory blood parameters tested. Conclusions Multistrain probiotic supplementation was found to be efficacious, safe and well tolerated in the elderly with functional constipation.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-022-01189-0</identifier><identifier>PMID: 35927504</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/2779/777 ; 692/700/1518 ; 692/700/459/1994 ; Aged ; Bifidobacterium animalis ; Blood ; Clinical Nutrition ; Constipation ; Constipation - drug therapy ; Constipation - microbiology ; Dietary supplements ; Double-Blind Method ; Epidemiology ; Feces - microbiology ; Female ; Humans ; Internal Medicine ; Laboratories ; Lactobacilli ; Lactobacillus acidophilus ; Male ; Medicine ; Medicine &amp; Public Health ; Metabolic Diseases ; Older people ; Parameters ; Placebos ; Probiotics ; Probiotics - therapeutic use ; Public Health</subject><ispartof>European journal of clinical nutrition, 2022-12, Vol.76 (12), p.1675-1681</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-41debea0f43c93e3c3a66fddcb031976e1b4262fb20593d4342f078e76749ee33</citedby><cites>FETCH-LOGICAL-c474t-41debea0f43c93e3c3a66fddcb031976e1b4262fb20593d4342f078e76749ee33</cites><orcidid>0000-0002-3213-6733 ; 0000-0002-9106-1604</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35927504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Šola, Katarina Fehir</creatorcontrib><creatorcontrib>Vladimir-Knežević, Sanda</creatorcontrib><creatorcontrib>Hrabač, Pero</creatorcontrib><creatorcontrib>Mucalo, Iva</creatorcontrib><creatorcontrib>Saso, Luciano</creatorcontrib><creatorcontrib>Verbanac, Donatella</creatorcontrib><title>The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background and objectives Constipation is one of the most common gastrointestinal conditions, particularly among older individuals. This study aimed to evaluate the efficacy and safety of selected multistrain probiotics on functional constipation and laboratory blood parameters in the elderly living in a nursing home. Subjects and methods Sixty participants (42 females and 18 males) aged 77.9 ± 8.84 years with functional constipation, who met the eligibility criteria, completed the study. In a double-blind, placebo-controlled, parallel design, each participant was randomized to receive either the selected probiotic mixture ( N  = 28) or placebo ( N  = 32) for 12 weeks as an adjunct to their usual diet and medications. The liquid probiotic formulation containing Bifidobacterium animalis subsp. lactis BLC1, Lactobacillus acidophilus LA3 and Lactobacillus casei BGP93 was tested for the first time. Results Supplementation of selected probiotics resulted in a slight but nonsignificant increase in cumulative stool frequency compared with placebo. However, after the 71st day of the treatment, the cumulative number of stools was significantly higher in the probiotic group ( P  &lt; 0.05) when the influence of laxative was excluded. The trend towards an increase in the difference between the two groups, which began 1 week after the probiotic intervention, pointed out to their prolonged effect. There were no significant dependent or independent effects of treatment and time on most of the 27 laboratory blood parameters tested. Conclusions Multistrain probiotic supplementation was found to be efficacious, safe and well tolerated in the elderly with functional constipation.</description><subject>692/308/2779/777</subject><subject>692/700/1518</subject><subject>692/700/459/1994</subject><subject>Aged</subject><subject>Bifidobacterium animalis</subject><subject>Blood</subject><subject>Clinical Nutrition</subject><subject>Constipation</subject><subject>Constipation - drug therapy</subject><subject>Constipation - microbiology</subject><subject>Dietary supplements</subject><subject>Double-Blind Method</subject><subject>Epidemiology</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Laboratories</subject><subject>Lactobacilli</subject><subject>Lactobacillus acidophilus</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Metabolic Diseases</subject><subject>Older people</subject><subject>Parameters</subject><subject>Placebos</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Public Health</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kUtv1TAQhS0EopfCH2CBLLFhExg_El-zQEIVL6kSm7K2HGfcunLii-0glV-Pwy3lsWDlsc43x-M5hDxl8JKB2L8qkkkBHXDeAWN73cE9smNSDV0_SLhPdqB72QkAdUIelXIN0ETFH5IT0WuuepA7Ml9cIUXv0VWaPJ3XWEOp2YaFHnIaQ6rBFZoW6tfF1ZAWG6lLS6nhYLcrbWDdLOKEOd68ppZmu0xpDt9x2siaU4ytrDnY-Jg88DYWfHJ7npIv799dnH3szj9_-HT29rxzUsnaSTbhiBa8FE4LFE7YYfDT5EYQTKsB2Sj5wP3IoddikkJyD2qPalBSIwpxSt4cfQ_rOOPksI1hoznkMNt8Y5IN5m9lCVfmMn0zWsG-17oZvLg1yOnriqWaORSHMdoF01oMH3RDlWQb-vwf9Dqtue2pUQ1gfS8G2Sh-pFxOpWT0d8MwMFua5pimaWman2kaaE3P_vzGXcuv-BogjkBp0nKJ-ffb_7H9Acm5rRE</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Šola, Katarina Fehir</creator><creator>Vladimir-Knežević, Sanda</creator><creator>Hrabač, Pero</creator><creator>Mucalo, Iva</creator><creator>Saso, Luciano</creator><creator>Verbanac, Donatella</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3213-6733</orcidid><orcidid>https://orcid.org/0000-0002-9106-1604</orcidid></search><sort><creationdate>20221201</creationdate><title>The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial</title><author>Šola, Katarina Fehir ; Vladimir-Knežević, Sanda ; Hrabač, Pero ; Mucalo, Iva ; Saso, Luciano ; Verbanac, Donatella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-41debea0f43c93e3c3a66fddcb031976e1b4262fb20593d4342f078e76749ee33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>692/308/2779/777</topic><topic>692/700/1518</topic><topic>692/700/459/1994</topic><topic>Aged</topic><topic>Bifidobacterium animalis</topic><topic>Blood</topic><topic>Clinical Nutrition</topic><topic>Constipation</topic><topic>Constipation - drug therapy</topic><topic>Constipation - microbiology</topic><topic>Dietary supplements</topic><topic>Double-Blind Method</topic><topic>Epidemiology</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Laboratories</topic><topic>Lactobacilli</topic><topic>Lactobacillus acidophilus</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Metabolic Diseases</topic><topic>Older people</topic><topic>Parameters</topic><topic>Placebos</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Public Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Šola, Katarina Fehir</creatorcontrib><creatorcontrib>Vladimir-Knežević, Sanda</creatorcontrib><creatorcontrib>Hrabač, Pero</creatorcontrib><creatorcontrib>Mucalo, Iva</creatorcontrib><creatorcontrib>Saso, Luciano</creatorcontrib><creatorcontrib>Verbanac, Donatella</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health &amp; Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied &amp; Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Šola, Katarina Fehir</au><au>Vladimir-Knežević, Sanda</au><au>Hrabač, Pero</au><au>Mucalo, Iva</au><au>Saso, Luciano</au><au>Verbanac, Donatella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>76</volume><issue>12</issue><spage>1675</spage><epage>1681</epage><pages>1675-1681</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background and objectives Constipation is one of the most common gastrointestinal conditions, particularly among older individuals. This study aimed to evaluate the efficacy and safety of selected multistrain probiotics on functional constipation and laboratory blood parameters in the elderly living in a nursing home. Subjects and methods Sixty participants (42 females and 18 males) aged 77.9 ± 8.84 years with functional constipation, who met the eligibility criteria, completed the study. In a double-blind, placebo-controlled, parallel design, each participant was randomized to receive either the selected probiotic mixture ( N  = 28) or placebo ( N  = 32) for 12 weeks as an adjunct to their usual diet and medications. The liquid probiotic formulation containing Bifidobacterium animalis subsp. lactis BLC1, Lactobacillus acidophilus LA3 and Lactobacillus casei BGP93 was tested for the first time. Results Supplementation of selected probiotics resulted in a slight but nonsignificant increase in cumulative stool frequency compared with placebo. However, after the 71st day of the treatment, the cumulative number of stools was significantly higher in the probiotic group ( P  &lt; 0.05) when the influence of laxative was excluded. The trend towards an increase in the difference between the two groups, which began 1 week after the probiotic intervention, pointed out to their prolonged effect. There were no significant dependent or independent effects of treatment and time on most of the 27 laboratory blood parameters tested. Conclusions Multistrain probiotic supplementation was found to be efficacious, safe and well tolerated in the elderly with functional constipation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35927504</pmid><doi>10.1038/s41430-022-01189-0</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3213-6733</orcidid><orcidid>https://orcid.org/0000-0002-9106-1604</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0954-3007
ispartof European journal of clinical nutrition, 2022-12, Vol.76 (12), p.1675-1681
issn 0954-3007
1476-5640
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9708599
source Nexis Advance UK (Federated Access); Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List
subjects 692/308/2779/777
692/700/1518
692/700/459/1994
Aged
Bifidobacterium animalis
Blood
Clinical Nutrition
Constipation
Constipation - drug therapy
Constipation - microbiology
Dietary supplements
Double-Blind Method
Epidemiology
Feces - microbiology
Female
Humans
Internal Medicine
Laboratories
Lactobacilli
Lactobacillus acidophilus
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Older people
Parameters
Placebos
Probiotics
Probiotics - therapeutic use
Public Health
title The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-22T18%3A36%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20multistrain%20probiotics%20on%20functional%20constipation%20in%20the%20elderly:%20a%20randomized%20controlled%20trial&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=%C5%A0ola,%20Katarina%20Fehir&rft.date=2022-12-01&rft.volume=76&rft.issue=12&rft.spage=1675&rft.epage=1681&rft.pages=1675-1681&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/s41430-022-01189-0&rft_dat=%3Cproquest_pubme%3E2741155364%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c474t-41debea0f43c93e3c3a66fddcb031976e1b4262fb20593d4342f078e76749ee33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2741155364&rft_id=info:pmid/35927504&rfr_iscdi=true