Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis

Objectives IL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin. Materials and methods Sixty-six adult pati...

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Bibliographic Details
Published in:Clinical oral investigations 2022-12, Vol.26 (12), p.7209-7218
Main Authors: Sari, Aysegul, Dogan, Serdar, Nibali, Luigi, Koseoglu, Serhat
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Cytokines
Dentistry
Disease
Enzyme-linked immunosorbent assay
Gingivitis
Gum disease
IL-1β
Interleukin 12
Medicine
Original
Original Article
Periodontal diseases
Periodontics
Periodontitis
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Summary:Objectives IL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin. Materials and methods Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1β, and periostin levels were examined using the enzyme-linked immunosorbent assay. Results GCF IL‑1β, periostin, and IL-39 levels were higher in the P and G groups than in the PH group ( p  
ISSN:1436-3771
1432-6981
1436-3771
DOI:10.1007/s00784-022-04681-w