Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis

Objectives IL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin. Materials and methods Sixty-six adult pati...

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Published in:Clinical oral investigations 2022-12, Vol.26 (12), p.7209-7218
Main Authors: Sari, Aysegul, Dogan, Serdar, Nibali, Luigi, Koseoglu, Serhat
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Cytokines
Dentistry
Disease
Enzyme-linked immunosorbent assay
Gingivitis
Gum disease
IL-1β
Interleukin 12
Medicine
Original
Original Article
Periodontal diseases
Periodontics
Periodontitis
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creator Sari, Aysegul
Dogan, Serdar
Nibali, Luigi
Koseoglu, Serhat
description Objectives IL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin. Materials and methods Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1β, and periostin levels were examined using the enzyme-linked immunosorbent assay. Results GCF IL‑1β, periostin, and IL-39 levels were higher in the P and G groups than in the PH group ( p  
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The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin. Materials and methods Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1β, and periostin levels were examined using the enzyme-linked immunosorbent assay. Results GCF IL‑1β, periostin, and IL-39 levels were higher in the P and G groups than in the PH group ( p  &lt; 0.001). Positive correlations were detected between all GCF biochemical parameters and clinical periodontal parameters ( p  &lt; 0.05). In the multivariate generalized linear regression analysis, the P (β = 37.6, 95% CI = 22.9–52.4) and G (β = 28.4, 95% CI = 15.8–41) groups were associated with GCF IL-39 levels ( p  &lt; 0.001). Conclusion IL-39 levels were elevated in the presence of periodontal disease paralleling the increase in IL‑1β and periostin levels. IL-39 may have a role in the periodontal inflammation process. Statement of clinical relevance IL-39, a new cytokine from the IL-12 family, can be a possible predictor marker of periodontal diseases.</description><identifier>ISSN: 1436-3771</identifier><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-022-04681-w</identifier><identifier>PMID: 35986791</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acute coronary syndromes ; Cytokines ; Dentistry ; Disease ; Enzyme-linked immunosorbent assay ; Gingivitis ; Gum disease ; IL-1β ; Interleukin 12 ; Medicine ; Original ; Original Article ; Periodontal diseases ; Periodontics ; Periodontitis</subject><ispartof>Clinical oral investigations, 2022-12, Vol.26 (12), p.7209-7218</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-a0019711b8240535571bed9a80654d1505b0deef57ace453b101884f5eb74543</citedby><cites>FETCH-LOGICAL-c381t-a0019711b8240535571bed9a80654d1505b0deef57ace453b101884f5eb74543</cites><orcidid>0000-0001-6854-2197 ; 0000-0001-6180-9776 ; 0000-0002-4121-2494 ; 0000-0002-7750-5010</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Sari, Aysegul</creatorcontrib><creatorcontrib>Dogan, Serdar</creatorcontrib><creatorcontrib>Nibali, Luigi</creatorcontrib><creatorcontrib>Koseoglu, Serhat</creatorcontrib><title>Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><description>Objectives IL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin. Materials and methods Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1β, and periostin levels were examined using the enzyme-linked immunosorbent assay. Results GCF IL‑1β, periostin, and IL-39 levels were higher in the P and G groups than in the PH group ( p  &lt; 0.001). Positive correlations were detected between all GCF biochemical parameters and clinical periodontal parameters ( p  &lt; 0.05). In the multivariate generalized linear regression analysis, the P (β = 37.6, 95% CI = 22.9–52.4) and G (β = 28.4, 95% CI = 15.8–41) groups were associated with GCF IL-39 levels ( p  &lt; 0.001). Conclusion IL-39 levels were elevated in the presence of periodontal disease paralleling the increase in IL‑1β and periostin levels. IL-39 may have a role in the periodontal inflammation process. 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The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin. Materials and methods Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1β, and periostin levels were examined using the enzyme-linked immunosorbent assay. Results GCF IL‑1β, periostin, and IL-39 levels were higher in the P and G groups than in the PH group ( p  &lt; 0.001). Positive correlations were detected between all GCF biochemical parameters and clinical periodontal parameters ( p  &lt; 0.05). 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subjects Acute coronary syndromes
Cytokines
Dentistry
Disease
Enzyme-linked immunosorbent assay
Gingivitis
Gum disease
IL-1β
Interleukin 12
Medicine
Original
Original Article
Periodontal diseases
Periodontics
Periodontitis
title Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis
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