Management of hyperinflammation in COVID-19 patients

In response to SARS-CoV-2 infection, the immune system physiologically upregulates to try to clear the virus from the body; failure to compensate for this inflammatory response with an anti-inflammatory response leads to dysregulation of the immune system that ultimately leads to a situation of unco...

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Bibliographic Details
Published in:Revista española de quimioterapia 2022-10, Vol.35 Suppl 3 (Suppl3), p.6-9
Main Authors: Suberviola, B, Cuenca Fito, E
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - therapeutic use
Approach to management of SARS-CoV-2 infection
COVID-19 - complications
Cytokine Release Syndrome - drug therapy
Cytokine Release Syndrome - etiology
Cytokines
Humans
SARS-CoV-2
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Summary:In response to SARS-CoV-2 infection, the immune system physiologically upregulates to try to clear the virus from the body; failure to compensate for this inflammatory response with an anti-inflammatory response leads to dysregulation of the immune system that ultimately leads to a situation of uncontrolled hyperinflammation called cytokine storm. This cytokine storm can cause ARDS or multi-organ failure leading to patient death. This review exposes the different mechanisms of the inflammatory response in COVID-19 infection and the therapeutic options to treat this process.
ISSN:0214-3429
1988-9518
1988-9518
DOI:10.37201/req/s03.02.2022