EphA2 Promotes the Development of Cervical Cancer through the CXCL11/PD-L1 Pathway

Erythropoietin-producing hepatoma receptor A2 (EphA2), receptor tyrosine kinase, the most widespread member of the largest receptor tyrosine kinase family, plays a critical role in physiological and pathological conditions. In recent years, the role of EphA2 in the occurrence and development of canc...

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Bibliographic Details
Published in:Journal of oncology 2022-11, Vol.2022, p.4886907-17
Main Authors: Zhao, Xinyue, Liu, Jiaxi, Jin, Dongdong, Ren, Chenchen, Yang, Li, Zhu, Yuanhang, Huang, Changhao, Ding, Leilei, Wu, Zimeng, Shen, Ke, Zhang, Zhen’an, Chen, Huanhuan, Wang, Nannan
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Biotechnology
Cancer therapies
Cell culture
Cell death
Cervical cancer
Enzymes
Fluorides
Kinases
Medical prognosis
Metastasis
Proteins
Reagents
Tumors
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Summary:Erythropoietin-producing hepatoma receptor A2 (EphA2), receptor tyrosine kinase, the most widespread member of the largest receptor tyrosine kinase family, plays a critical role in physiological and pathological conditions. In recent years, the role of EphA2 in the occurrence and development of cancer has become a research hotspot and is considered a promising potential target. Our previous studies have shown that EphA2 has an indisputable cancer-promoting role in cervical cancer, but its related mechanism requires further research. In this study, high-throughput sequencing was performed on EphA2 knockdown cervical cancer cells and the control group. An analysis of differentially expressed genes revealed that EphA2 may exert its cancer-promoting effect through C-X-C motif chemokine ligand 11 (CXCL11). In addition, we found that EphA2 could further regulate programmed cell death ligand 1 (PD-L1) through CXCL11. This has also been further demonstrated in in vivo experiments. Our study demonstrated that EphA2 plays a tumor-promoting role in cervical carcinoma through the CXCL11/PD-L1 pathway, providing new guidance for the targeted therapy and combination therapy of cervical carcinoma.
ISSN:1687-8450
1687-8450
DOI:10.1155/2022/4886907