Molecular docking analysis of syringic acid with proteins in inflammatory cascade

Syringic Acid (SA) is a dimethoxybenzene derived from plants. Dietary SA possesses anti-obesity, anti-inflammatory and anti-steatotic effects and is of interest as a potential therapeutic medication in the treatment of obesity, diabetes, diabetic cataracts and asthma. It has anti-tumorigenic effect...

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Bibliographic Details
Published in:Bioinformation 2022-03, Vol.18 (3), p.219-225
Main Authors: Sukumaran, Gheena, Ezhilarasan, Devaraj, Ramani, Pratibha, Merlin, R Jancy
Format: Article
Language:English
Subjects:
Acetaminophen
Asthma
Cancer
Cataracts
Diabetes mellitus
Diet
Hepatocellular carcinoma
Inflammation
Lung carcinoma
Molecular docking
Mucosa
NF-κB protein
Obesity
Oral carcinoma
Proteins
Tumor necrosis factor
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Summary:Syringic Acid (SA) is a dimethoxybenzene derived from plants. Dietary SA possesses anti-obesity, anti-inflammatory and anti-steatotic effects and is of interest as a potential therapeutic medication in the treatment of obesity, diabetes, diabetic cataracts and asthma. It has anti-tumorigenic effect against hepatocellular carcinoma, lung carcinoma and oral mucosal carcinoma. It is also believed to have a protective effect on Acetaminophen induced damage in Wistar rats. Therefore, it is of interest to document the molecular docking analysis of syringic acid with proteins in inflammatory cascade such as TNF α, NFκB, P50, P65 and IKB for further consideration in drug discovery.
ISSN:0973-2063
0973-8894
0973-2063
DOI:10.6026/97320630018219