Effects of Buprenorphine and Carprofen on Appetite in New Zealand White Rabbits (Oryctolagus cuniculus)

• Published in: Journal of the American Association for Laboratory Animal Science 2022-11, Vol.61 (6), p.672-677, Article 672
• Main Authors: Hsi, Zoe Y, Theil, Jacob H, Ma, Betty W, Oates, Rhonda S
• Format: Article
• Language: English
• Subjects: Analgesics - therapeutic use; Analgesics, Opioid; Animals; Appetite; Buprenorphine; Female; Male; Original Research; Pain, Postoperative - drug therapy; Rabbits
• ISSN: 1559-6109; 2769-6677
• DOI: 10.30802/AALAS-JAALAS-22-000057

Rabbits are especially susceptible to adverse effects related to surgery, which can lead to inappetence and gastrointestinal (GI) stasis. However, these adverse effects may be related to discomfort from the procedure, anesthesia, the analgesics used, and the stress of restraint for analgesic administration. Opioid and NSAID analgesics which are frequently used in rabbits, can contribute to these adverse effects. This study compared the clinical GI side effects of buprenorphine and carprofen to saline controls in New Zealand White rabbits after a nonsurgical anesthetic event. Nine rabbits (3 females and 6 males, aged 8 to 20 mo) were randomly rotated through 5 treatment groups with a 7-d washout period between treatments: anesthesia control (no treatment), buprenorphine (0.05 mg/kg SC every 12 h for 72 h), carprofen (5 mg/kg SC every 24 h for 72 h), twice daily saline control (equivalent volume to buprenorphine SC every 12 h for 72 h), and once daily saline control (equivalent volume to carprofen SC every 24 h for 72 h). All rabbits were anesthetized 5 times and received initial treatments on the day of anesthesia. Generalized linear mixed models were used to assess food intake, water intake, and fecal output score for 7 days after anesthesia. Analysis showed that buprenorphine-treated rabbits had a significant 4-d decrease in food intake and a 3-d decrease in fecal output score compared with baseline. None of the other treatment groups showed any changes in food intake or fecal output score compared with baseline. These findings demonstrate that in the absence of pain, buprenorphine significantly depresses food intake in rabbits and that restraint and injections have minimal effect on food intake despite the possibility of increased stress.