The Key Role of Glutathione Compared to Curcumin in the Management of Systemic Lupus Erythematosus: A Systematic Review

In recent years, many documented cases of systemic lupus erythematosus (SLE) have been on the rise. The complicated pathophysiology of the disease makes it challenging to manage. Two databases, PubMed and Google Scholar, have a detailed screening using keywords and Medical Subject Heading (MeSH) com...

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Published in:Curēus (Palo Alto, CA) CA), 2022-11, Vol.14 (11), p.e31324
Main Authors: Ravi, Niriksha, Choday, Silpa, Shantha Kumar, Vivig, Kc, Anil, Parisapogu, Anusha, Ojinna, Blessing T, Tran, Hadrian Hoang-Vu, Sherpa, Mingma L, Shrestha, Nilasma, Mohammed, Lubna
Format: Article
Language:English
Subjects:
Adaptive immunity
Bias
Bone marrow
Drug dosages
Drug therapy
Epidemiology
Immunology
Internal Medicine
Lupus
Pathophysiology
Pharmacokinetics
Physiology
Quality Improvement
Remission (Medicine)
Rheumatology
Systematic review
Tumor necrosis factor-TNF
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Summary:In recent years, many documented cases of systemic lupus erythematosus (SLE) have been on the rise. The complicated pathophysiology of the disease makes it challenging to manage. Two databases, PubMed and Google Scholar, have a detailed screening using keywords and Medical Subject Heading (MeSH) combinations. The words are "Systemic Lupus Erythematosus OR SLE OR Lupus," "Glutathione," and "Curcumin." Articles had a detailed process of screening and quality appraisal. Using the English language as a primary filtering parameter, papers over the last 20 years, dating from 2002 to 2022, are the basis of this review. We reviewed all possible human studies documenting the use of curcumin and glutathione for treating SLE. A total of 15 articles are part of this systematic review. Curcumin and glutathione can act as potent drugs for treating lupus. Curcumin can be a more promising alternative since it operates on various pathways and is a more easily accessible source.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.31324