Enhancing bioactivity and stability of polymer-based material-tissue interface through coupling multiscale interfacial interactions with atomic-thin TiO2 nanosheets

Stable and bioactive material—tissue interface (MTF) basically determines the clinical applications of biomaterials in wound healing, sustained drug release, and tissue engineering. Although many inorganic nanomaterials have been widely explored to enhance the stability and bioactivity of polymer-ba...

Full description

Saved in:
Bibliographic Details
Published in:Nano research 2023-04, Vol.16 (4), p.5247-5255
Main Authors: Xu, Rongchen, Mu, Xiaodan, Hu, Zunhan, Jia, Chongzhi, Yang, Zhenyu, Yang, Zhongliang, Fan, Yiping, Wang, Xiaoyu, Wu, Yuefeng, Lu, Xiaotong, Chen, Jihua, Xiang, Guolei, Li, Hongbo
Format: Article
Language:English
Subjects:
Adhesives
Atomic/Molecular Structure and Spectra
Biocompatibility
Biological activity
Biomaterials
Biomedical materials
Biomedicine
Biotechnology
Chemistry and Materials Science
Collagen
Composite materials
Condensed Matter Physics
Coupling
Demineralizing
Dental pulp
Dental restorative materials
Drug delivery systems
Enzymes
Hydrogels
Hydroxyapatite
Interface stability
Interfaces
Materials Science
Mechanical properties
Nanomaterials
Nanoparticles
Nanosheets
Nanotechnology
Polymer matrix composites
Polymers
Proteins
Research Article
Resins
Stem cells
Tissue engineering
Titanium dioxide
Trends
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Stable and bioactive material—tissue interface (MTF) basically determines the clinical applications of biomaterials in wound healing, sustained drug release, and tissue engineering. Although many inorganic nanomaterials have been widely explored to enhance the stability and bioactivity of polymer-based biomaterials, most are still restricted by their stability and biocompatibility. Here we demonstrate the enhanced bioactivity and stability of polymer-matrix bio-composite through coupling multiscale material—tissue interfacial interactions with atomically thin TiO 2 nanosheets. Resin modified with TiO 2 nanosheets displays improved mechanical properties, hydrophilicity, and stability. Also, we confirm that this resin can effectively stimulate the adhesion, proliferation, and differentiation into osteogenic and odontogenic lineages of human dental pulp stem cells using in vitro cell—resin interface model. TiO 2 nanosheets can also enhance the interaction between demineralized dentinal collagen and resin. Our results suggest an approach to effectively up-regulate the stability and bioactivity of MTFs by designing biocompatible materials at the sub-nanoscale.
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-022-5153-1