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Enhancing bioactivity and stability of polymer-based material-tissue interface through coupling multiscale interfacial interactions with atomic-thin TiO2 nanosheets
Stable and bioactive material—tissue interface (MTF) basically determines the clinical applications of biomaterials in wound healing, sustained drug release, and tissue engineering. Although many inorganic nanomaterials have been widely explored to enhance the stability and bioactivity of polymer-ba...
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| Published in: | Nano research 2023-04, Vol.16 (4), p.5247-5255 |
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| container_end_page | 5255 |
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| container_title | Nano research |
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| creator | Xu, Rongchen Mu, Xiaodan Hu, Zunhan Jia, Chongzhi Yang, Zhenyu Yang, Zhongliang Fan, Yiping Wang, Xiaoyu Wu, Yuefeng Lu, Xiaotong Chen, Jihua Xiang, Guolei Li, Hongbo |
| description | Stable and bioactive material—tissue interface (MTF) basically determines the clinical applications of biomaterials in wound healing, sustained drug release, and tissue engineering. Although many inorganic nanomaterials have been widely explored to enhance the stability and bioactivity of polymer-based biomaterials, most are still restricted by their stability and biocompatibility. Here we demonstrate the enhanced bioactivity and stability of polymer-matrix bio-composite through coupling multiscale material—tissue interfacial interactions with atomically thin TiO
2
nanosheets. Resin modified with TiO
2
nanosheets displays improved mechanical properties, hydrophilicity, and stability. Also, we confirm that this resin can effectively stimulate the adhesion, proliferation, and differentiation into osteogenic and odontogenic lineages of human dental pulp stem cells using
in vitro
cell—resin interface model. TiO
2
nanosheets can also enhance the interaction between demineralized dentinal collagen and resin. Our results suggest an approach to effectively up-regulate the stability and bioactivity of MTFs by designing biocompatible materials at the sub-nanoscale. |
| doi_str_mv | 10.1007/s12274-022-5153-1 |
| format | article |
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2
nanosheets. Resin modified with TiO
2
nanosheets displays improved mechanical properties, hydrophilicity, and stability. Also, we confirm that this resin can effectively stimulate the adhesion, proliferation, and differentiation into osteogenic and odontogenic lineages of human dental pulp stem cells using
in vitro
cell—resin interface model. TiO
2
nanosheets can also enhance the interaction between demineralized dentinal collagen and resin. Our results suggest an approach to effectively up-regulate the stability and bioactivity of MTFs by designing biocompatible materials at the sub-nanoscale.</description><identifier>ISSN: 1998-0124</identifier><identifier>EISSN: 1998-0000</identifier><identifier>DOI: 10.1007/s12274-022-5153-1</identifier><language>eng</language><publisher>Beijing: Tsinghua University Press</publisher><subject>Adhesives ; Atomic/Molecular Structure and Spectra ; Biocompatibility ; Biological activity ; Biomaterials ; Biomedical materials ; Biomedicine ; Biotechnology ; Chemistry and Materials Science ; Collagen ; Composite materials ; Condensed Matter Physics ; Coupling ; Demineralizing ; Dental pulp ; Dental restorative materials ; Drug delivery systems ; Enzymes ; Hydrogels ; Hydroxyapatite ; Interface stability ; Interfaces ; Materials Science ; Mechanical properties ; Nanomaterials ; Nanoparticles ; Nanosheets ; Nanotechnology ; Polymer matrix composites ; Polymers ; Proteins ; Research Article ; Resins ; Stem cells ; Tissue engineering ; Titanium dioxide ; Trends ; Wound healing</subject><ispartof>Nano research, 2023-04, Vol.16 (4), p.5247-5255</ispartof><rights>Tsinghua University Press 2022</rights><rights>Tsinghua University Press 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-b7090addb91ff1fca24db8d0cc95c110e5cbdfc85573b5f6f4b4ce1056bdd6d83</citedby><cites>FETCH-LOGICAL-c447t-b7090addb91ff1fca24db8d0cc95c110e5cbdfc85573b5f6f4b4ce1056bdd6d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Xu, Rongchen</creatorcontrib><creatorcontrib>Mu, Xiaodan</creatorcontrib><creatorcontrib>Hu, Zunhan</creatorcontrib><creatorcontrib>Jia, Chongzhi</creatorcontrib><creatorcontrib>Yang, Zhenyu</creatorcontrib><creatorcontrib>Yang, Zhongliang</creatorcontrib><creatorcontrib>Fan, Yiping</creatorcontrib><creatorcontrib>Wang, Xiaoyu</creatorcontrib><creatorcontrib>Wu, Yuefeng</creatorcontrib><creatorcontrib>Lu, Xiaotong</creatorcontrib><creatorcontrib>Chen, Jihua</creatorcontrib><creatorcontrib>Xiang, Guolei</creatorcontrib><creatorcontrib>Li, Hongbo</creatorcontrib><title>Enhancing bioactivity and stability of polymer-based material-tissue interface through coupling multiscale interfacial interactions with atomic-thin TiO2 nanosheets</title><title>Nano research</title><addtitle>Nano Res</addtitle><description>Stable and bioactive material—tissue interface (MTF) basically determines the clinical applications of biomaterials in wound healing, sustained drug release, and tissue engineering. Although many inorganic nanomaterials have been widely explored to enhance the stability and bioactivity of polymer-based biomaterials, most are still restricted by their stability and biocompatibility. Here we demonstrate the enhanced bioactivity and stability of polymer-matrix bio-composite through coupling multiscale material—tissue interfacial interactions with atomically thin TiO
2
nanosheets. Resin modified with TiO
2
nanosheets displays improved mechanical properties, hydrophilicity, and stability. Also, we confirm that this resin can effectively stimulate the adhesion, proliferation, and differentiation into osteogenic and odontogenic lineages of human dental pulp stem cells using
in vitro
cell—resin interface model. TiO
2
nanosheets can also enhance the interaction between demineralized dentinal collagen and resin. Our results suggest an approach to effectively up-regulate the stability and bioactivity of MTFs by designing biocompatible materials at the sub-nanoscale.</description><subject>Adhesives</subject><subject>Atomic/Molecular Structure and Spectra</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Chemistry and Materials Science</subject><subject>Collagen</subject><subject>Composite materials</subject><subject>Condensed Matter Physics</subject><subject>Coupling</subject><subject>Demineralizing</subject><subject>Dental pulp</subject><subject>Dental restorative materials</subject><subject>Drug delivery systems</subject><subject>Enzymes</subject><subject>Hydrogels</subject><subject>Hydroxyapatite</subject><subject>Interface stability</subject><subject>Interfaces</subject><subject>Materials Science</subject><subject>Mechanical properties</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanosheets</subject><subject>Nanotechnology</subject><subject>Polymer matrix composites</subject><subject>Polymers</subject><subject>Proteins</subject><subject>Research Article</subject><subject>Resins</subject><subject>Stem cells</subject><subject>Tissue engineering</subject><subject>Titanium dioxide</subject><subject>Trends</subject><subject>Wound 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Res</stitle><date>2023-04-01</date><risdate>2023</risdate><volume>16</volume><issue>4</issue><spage>5247</spage><epage>5255</epage><pages>5247-5255</pages><issn>1998-0124</issn><eissn>1998-0000</eissn><abstract>Stable and bioactive material—tissue interface (MTF) basically determines the clinical applications of biomaterials in wound healing, sustained drug release, and tissue engineering. Although many inorganic nanomaterials have been widely explored to enhance the stability and bioactivity of polymer-based biomaterials, most are still restricted by their stability and biocompatibility. Here we demonstrate the enhanced bioactivity and stability of polymer-matrix bio-composite through coupling multiscale material—tissue interfacial interactions with atomically thin TiO
2
nanosheets. Resin modified with TiO
2
nanosheets displays improved mechanical properties, hydrophilicity, and stability. Also, we confirm that this resin can effectively stimulate the adhesion, proliferation, and differentiation into osteogenic and odontogenic lineages of human dental pulp stem cells using
in vitro
cell—resin interface model. TiO
2
nanosheets can also enhance the interaction between demineralized dentinal collagen and resin. Our results suggest an approach to effectively up-regulate the stability and bioactivity of MTFs by designing biocompatible materials at the sub-nanoscale.</abstract><cop>Beijing</cop><pub>Tsinghua University Press</pub><doi>10.1007/s12274-022-5153-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1998-0124 |
| ispartof | Nano research, 2023-04, Vol.16 (4), p.5247-5255 |
| issn | 1998-0124 1998-0000 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9734535 |
| source | Springer Nature |
| subjects | Adhesives Atomic/Molecular Structure and Spectra Biocompatibility Biological activity Biomaterials Biomedical materials Biomedicine Biotechnology Chemistry and Materials Science Collagen Composite materials Condensed Matter Physics Coupling Demineralizing Dental pulp Dental restorative materials Drug delivery systems Enzymes Hydrogels Hydroxyapatite Interface stability Interfaces Materials Science Mechanical properties Nanomaterials Nanoparticles Nanosheets Nanotechnology Polymer matrix composites Polymers Proteins Research Article Resins Stem cells Tissue engineering Titanium dioxide Trends Wound healing |
| title | Enhancing bioactivity and stability of polymer-based material-tissue interface through coupling multiscale interfacial interactions with atomic-thin TiO2 nanosheets |
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