IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies

Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action, mediating innate and adaptive immunity and multiple physiological processes, including protective and regenerative ones. IL-8 is a pro-inflammatory CXC chemokine with a primary function in attracting and activat...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-11, Vol.23 (23), p.14574
Main Authors: Vilotić, Aleksandra, Nacka-Aleksić, Mirjana, Pirković, Andrea, Bojić-Trbojević, Žanka, Dekanski, Dragana, Jovanović Krivokuća, Milica
Format: Article
Language:English
Subjects:
Achievement tests
Adaptive immunity
Chemokines
Cytokines
Diabetes mellitus
Embryos
Endometrium
Female
Fertility
Humans
In vitro fertilization
Inflammation
Interleukin 6
Interleukin 8
Interleukin-8 - genetics
Kinases
Leukocytes (neutrophilic)
Literature reviews
Menstruation
Parturition
Physiology
Placenta
Pre-Eclampsia
Pregnancy
Pregnancy complications
Proteins
Review
Reviews
Signal transduction
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Summary:Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action, mediating innate and adaptive immunity and multiple physiological processes, including protective and regenerative ones. IL-8 is a pro-inflammatory CXC chemokine with a primary function in attracting and activating neutrophils, but also implicated in a variety of other cellular processes. These two ILs are abundantly expressed at the feto-maternal interface over the course of a pregnancy and have been shown to participate in numerous pregnancy-related events. In this review, we summarize the literature data regarding their role in healthy and pathological pregnancies. The general information related to IL-6 and IL-8 functions is followed by an overview of their overall expression in cycling endometrium and at the feto-maternal interface. Further, we provide an overview of their involvement in pregnancy establishment and parturition. Finally, the implication of IL-6 and IL-8 in pregnancy-associated pathological conditions, such as pregnancy loss, preeclampsia, gestational diabetes mellitus and infection/inflammation is discussed.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232314574