Electrocardiographic Parameters Associated with Adverse Outcomes in Children with Cardiomyopathies

Cardiomyopathies have a low prevalence in children and thus may lead to malignant ventricular arrhythmias or the progression of heart failure, resulting in death. In adults, the QRS-T angle derived from ECG has been associated with adverse outcomes in patients with hypertrophic and dilated cardiomyo...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-11, Vol.11 (23), p.6930
Main Authors: Luczak-Wozniak, Katarzyna, Obsznajczyk, Klaudia, Niszczota, Cezary, Werner, Bożena
Format: Article
Language:English
Subjects:
Cardiac arrhythmia
Cardiomyopathy
Ejection fraction
Electrocardiography
Heart failure
Heart rate
Heart transplants
Pathophysiology
Statistical analysis
Survival analysis
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Summary:Cardiomyopathies have a low prevalence in children and thus may lead to malignant ventricular arrhythmias or the progression of heart failure, resulting in death. In adults, the QRS-T angle derived from ECG has been associated with adverse outcomes in patients with hypertrophic and dilated cardiomyopathies. We aimed to assess the electrocardiographic parameters, including QRS-T angle, associated with adverse cardiac events in children with cardiomyopathies. Forty-two children with cardiomyopathies were included in this study: 19 with dilated cardiomyopathy, 17 with hypertrophic cardiomyopathy, and 6 with left ventricular non-compaction. Additionally, 19 control subjects were recruited. In terms of ECG parameters, the QRS-T angle was significantly greater among patients with adverse outcomes compared to patients without the end points of the study (133° vs. 65°, p < 0.001). On Kaplan−Meier survival curves, QRS-T angle > 120°, increased serum concentrations of NT-proBNP and troponin I levels as well as greater NYHA or Ross scale were associated with the greatest risk of unfavorable outcome. The QRS-T angle appears to be a valuable component of 12-lead ECG interpretation, and might be helpful in outlining patients with the greatest cardiovascular risk. Additionally, serum biomarkers such as NT-proBNP (p = 0.003) and troponin (p < 0.001) are useful in outlining patients with the worst survival.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11236930