Characteristics of Gut Microbiota in Small for Gestational Age Infants with Very Low Birth Weight

Small for gestational age (SGA) birth is associated with high rates of mortality and morbidity in preterm infants. The aim of this preliminary observational study was to investigate the difference in gut microbiota between SGA and appropriate for gestational age (AGA) preterm infants with very low b...

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Bibliographic Details
Published in:Nutrients 2022-12, Vol.14 (23), p.5158
Main Authors: Chang, Hung-Yang, Chiang Chiau, Jen-Shiu, Chang, Jui-Hsing, Hsu, Chyong-Hsin, Lin, Chia-Ying, Ko, Mary Hsin-Ju, Lee, Hung-Chang
Format: Article
Language:English
Subjects:
Abundance
Antibiotics
Birth Weight
Community structure
DNA sequencing
Female
Fetal Growth Retardation
Gestational Age
Health aspects
Hospitals
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Small for Gestational Age
Infant, Very Low Birth Weight
Infants
Infants (Premature)
Intensive care
Intestinal microflora
Klebsiella
Low birth weight
Metabolism
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Morbidity
Mortality
Neonates
Newborn babies
Nucleotide sequencing
Preeclampsia
Premature babies
Probiotics
Small for gestational age
Taiwan
Veganism
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Summary:Small for gestational age (SGA) birth is associated with high rates of mortality and morbidity in preterm infants. The aim of this preliminary observational study was to investigate the difference in gut microbiota between SGA and appropriate for gestational age (AGA) preterm infants with very low birth weight (VLBW). We included 20 VLBW preterm infants (SGA, = 10; AGA, = 10) in this study. Stool samples were collected on days 7, 14, and 30 after birth. We performed 16S ribosomal DNA sequencing to compare microbiota composition between both groups. The SGA group exhibited a lower abundance of on day 14 (SGA, 0.57%; AGA, 7.42%; = 0.037). On day 30, the SGA group exhibited a lower abundance of (SGA 3.76% vs. AGA 16.05%; = 0.07) and (SGA 5.09% vs. AGA 27.25%; = 0.011) than the AGA group. Beta diversity demonstrated a separation of the bacterial community structure between both groups on day 30 ( = 0.019). The present study revealed that a distinct gut microbiota profile gradually develops in SGA preterm infants with VLBW during the early days of life. The role of changes in gut microbiota structure warrants further investigation.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14235158