Tissue Reactions and Mechanism in Cardiovascular Diseases Induced by Radiation

The long-term survival rate of cancer patients has been increasing as a result of advances in treatments and precise medical management. The evidence has accumulated that the incidence and mortality of non-cancer diseases have increased along with the increase in survival time and long-term survival...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-11, Vol.23 (23), p.14786
Main Authors: Liu, Xiao-Chang, Zhou, Ping-Kun
Format: Article
Language:English
Subjects:
Apoptosis
Arteriosclerosis
Atherosclerosis
Atherosclerosis - etiology
Blood vessels
Cancer
Cancer therapies
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - complications
Clinical trials
Coronary vessels
DNA damage
Endothelial Cells
Endothelium
Epidemiology
Fibrosis
Heart
Hemodynamics
Humans
Injuries
Ischemia
Leukocytes (neutrophilic)
Medical research
Membrane permeability
Mortality
Neoplasms - complications
Neoplasms - radiotherapy
Patients
Permeability
Post-irradiation
Pulmonary arteries
Radiation damage
Radiation effects
Radiation Injuries - complications
Radiation therapy
Review
Senescence
Stem cells
Survival
Vasculitis
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Summary:The long-term survival rate of cancer patients has been increasing as a result of advances in treatments and precise medical management. The evidence has accumulated that the incidence and mortality of non-cancer diseases have increased along with the increase in survival time and long-term survival rate of cancer patients after radiotherapy. The risk of cardiovascular disease as a radiation late effect of tissue damage reactions is becoming a critical challenge and attracts great concern. Epidemiological research and clinical trials have clearly shown the close association between the development of cardiovascular disease in long-term cancer survivors and radiation exposure. Experimental biological data also strongly supports the above statement. Cardiovascular diseases can occur decades post-irradiation, and from initiation and development to illness, there is a complicated process, including direct and indirect damage of endothelial cells by radiation, acute vasculitis with neutrophil invasion, endothelial dysfunction, altered permeability, tissue reactions, capillary-like network loss, and activation of coagulator mechanisms, fibrosis, and atherosclerosis. We summarize the most recent literature on the tissue reactions and mechanisms that contribute to the development of radiation-induced cardiovascular diseases (RICVD) and provide biological knowledge for building preventative strategies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232314786