Osteoporosis Risk in Hemodialysis Patients: The Roles of Gender, Comorbidities, Biochemical Parameters, Health and Diet Literacy

• Published in: Nutrients 2022-12, Vol.14 (23), p.5122
• Main Authors: Le, Lan T H, Dang, Loan T, Wang, Tsae-Jyy, Do, Tuyen G, Nguyen, Dung H, Hoang, Trung A, Pham, Minh D, Do, Binh N, Nguyen, Hoang C, Tran, Tu T, Pham, Linh V, Nguyen, Lien T H, Nguyen, Hoi T, Trieu, Nga T, Do, Thinh V, Trinh, Manh V, Ha, Tung H, Phan, Dung T, Yang, Shwu-Huey, Le, Ngoc N M, Nguyen, Kien T, Duong, Tuyen Van
• Format: Article
• Language: English
• Subjects: Albumin; Albumins; Arthritis; Blood; Comorbidity; Confidence intervals; Coronaviruses; COVID-19; Cross-Sectional Studies; Diet; Diet, Healthy; Education; Exercise; Female; Fractures; Gender; Health aspects; Health education; Health Literacy; Hematocrit; Hemodialysis; Hemoglobin; Hospitals; Humans; Literacy; Low level; Male; Medical research; Medicine, Experimental; Morbidity; Mortality; Osteoporosis; Osteoporosis - epidemiology; Osteoporosis - etiology; Patients; Physical activity; Questionnaires; Regression analysis; Rheumatoid arthritis; Rheumatoid factor; Risk; Risk factors; Self assessment; Self evaluation; Sociodemographics; Statistical analysis; Surveys and Questionnaires; Taiwan; Ulcers; Vietnam; Womens health
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu14235122

Osteoporosis is a common bone health disorder in hemodialysis patients that is linked with a higher morbidity and mortality rate. While previous studies have explored the associated factors of osteoporosis, there is a lack of studies investigating the impacts of health literacy (HL) and digital healthy diet literacy (DDL) on osteoporosis. Therefore, we aimed to investigate the associations of HL, DDL, and other factors with osteoporosis among hemodialysis patients. From July 2020 to March 2021, a cross-sectional study was conducted on 675 hemodialysis patients in eight hospitals in Vietnam. The data were collected by using the osteoporosis self-assessment tool for Asians (OSTA) and the 12-item short form of the health literacy questionnaire (HLS-SF12) on digital healthy diet literacy (DDL) and hemodialysis dietary knowledge (HDK). In addition, we also collected information about the socio-demographics, the clinical parameters, the biochemical parameters, and physical activity. Unadjusted and adjusted multinomial logistic regression models were utilized in order to investigate the associations. The proportion of patients at low, medium, and high levels of osteoporosis risk was 39.6%, 40.6%, and 19.8%, respectively. In the adjusted models, women had a higher likelihood of osteoporosis risk than men (odds ratio, OR, 3.46; 95% confidence interval, 95% CI, 1.86, 6.44; p < 0.001; and OR, 6.86; 95% CI, 2.96, 15.88; p < 0.001). The patients with rheumatoid arthritis (OR, 4.37; 95% CI, 1.67, 11.52; p = 0.003) and stomach ulcers (OR, 1.95; 95% CI, 1.01, 3.77; p = 0.048) were more likely to have a higher likelihood of osteoporosis risk than those without. The patients who had a higher waist circumference (WC), HL, and DDL were less likely to have a medium level of osteoporosis risk (OR, 0.95; 95% CI, 0.92, 0.98; p = 0.004; OR, 0.92; 95% CI, 0.88, 0.96; p < 0.001; OR, 0.96; 95% CI, 0.93, 0.99; p = 0.017, respectively) and a high level of osteoporosis risk (OR, 0.93; 95% CI, 0.89, 0.97; p = 0.001; OR, 0.89; 95% CI, 0.84, 0.94; p < 0.001; OR, 0.95; 95% CI, 0.91, 0.99; p = 0.008, respectively) compared with a low level of osteoporosis risk and to those with a lower WC, HL, and DDL. In addition, higher levels of hemoglobin (Hb) (OR, 0.79; 95% CI, 0.66, 0.95; p = 0.014), hematocrit (Hct) (OR, 0.95; 95% CI, 0.92, 0.99; p = 0.041), albumin (OR, 0.91; 95% CI, 0.83, 0.99; p = 0.030), and education (OR, 0.37; 95% CI, 0.16, 0.88; p = 0.025) were associated with a lower likelihoo