Metformin use and mortality in Asian, diabetic patients with prostate cancer on androgen deprivation therapy: A population‐based study

Background This study aims to examine the associations between metformin use concurrent with androgen deprivation therapy (ADT) and mortality risks in Asian, diabetic patients with prostate cancer (PCa). Methods This study identified diabetic adults with PCa receiving any ADT attending public hospit...

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Bibliographic Details
Published in:The Prostate 2023-01, Vol.83 (1), p.119-127
Main Authors: Lee, Yan Hiu Athena, Hui, Jeremy Man Ho, Chan, Jeffrey Shi Kai, Liu, Kang, Dee, Edward C., Ng, Kenrick, Tang, Pias, Tse, Gary, Ng, Chi Fai
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Androgen Antagonists - adverse effects
Androgen receptors
Androgens
Antidiabetics
Castration
Chemotherapy
Cohort analysis
cohort studies
Diabetes
Diabetes mellitus
Diabetes Mellitus - drug therapy
Diabetes Mellitus - epidemiology
Humans
Kidney diseases
Male
Metformin
Metformin - therapeutic use
Mortality
Orchidectomy
Original
Patients
Population studies
Population-based studies
Prostate cancer
prostatic neoplasms
Prostatic Neoplasms - drug therapy
Retrospective Studies
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Summary:Background This study aims to examine the associations between metformin use concurrent with androgen deprivation therapy (ADT) and mortality risks in Asian, diabetic patients with prostate cancer (PCa). Methods This study identified diabetic adults with PCa receiving any ADT attending public hospitals in Hong Kong between December 1999 and March 2021 retrospectively, with follow‐up until September 2021. Patients with
ISSN:0270-4137
1097-0045
1097-0045
DOI:10.1002/pros.24443