Periodontitis and Preeclampsia in Pregnancy: A Systematic Review and Meta-Analysis

Objectives A conflicting body of evidence suggests localized periodontal inflammation spreads systemically during pregnancy inducing adverse pregnancy outcomes. This systematic review and meta-analysis aim to specifically evaluate the relationship between periodontitis and preeclampsia. Methods Elec...

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Published in:Maternal and child health journal 2022-12, Vol.26 (12), p.2419-2443
Main Authors: Le, Quynh-Anh, Akhter, Rahena, Coulton, Kimberly Mathieu, Vo, Ngoc Truong Nhu, Duong, Le Thi Yen, Nong, Hoang Viet, Yaacoub, Albert, Condous, George, Eberhard, Joerg, Nanan, Ralph
Format: Article
Language:English
Subjects:
Cohort analysis
Complications and side effects
Developing countries
Female
Gum disease
Gynecology
Health aspects
Heterogeneity
Humans
Maternal and Child Health
Medicine
Medicine & Public Health
Meta-analysis
Odds Ratio
Pediatrics
Periodontal diseases
Periodontal Diseases - complications
Periodontitis
Periodontitis - complications
Periodontitis - epidemiology
Population Economics
Pre-Eclampsia - epidemiology
Pre-Eclampsia - etiology
Preeclampsia
Pregnancy
Pregnancy Outcome - epidemiology
Pregnant women
Public Health
Risk factors
Sociology
Systematic review
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Summary:Objectives A conflicting body of evidence suggests localized periodontal inflammation spreads systemically during pregnancy inducing adverse pregnancy outcomes. This systematic review and meta-analysis aim to specifically evaluate the relationship between periodontitis and preeclampsia. Methods Electronic searches were carried out in Medline, Pubmed, Embase, Lilacs, Cochrane Controlled Clinical Trial Register, CINAHL, ClinicalTrials.gov, and Google Scholar with no restrictions on the year of publication. We identified and selected observational case–control and cohort studies that analyzed the association between periodontal disease and preeclampsia. This meta-analysis was conducted following the PRISMA checklist and MOOSE checklist. Pooled odds ratios, mean difference, and 95% confidence intervals were calculated using the random effect model. Heterogeneity was tested with Cochran’s Q statistic. Results Thirty studies including six cohort- and twenty-four case–control studies were selected. Periodontitis was significantly associated with increased risk for preeclampsia (OR 3.18, 95% CI 2.26 – 4.48, p 
ISSN:1092-7875
1573-6628
DOI:10.1007/s10995-022-03556-6