Molecular mechanisms of multidrug resistance in clinically relevant enteropathogenic bacteria (Review)

Multidrug resistant (MDR) enteropathogenic bacteria are a growing problem within the clinical environment due to their acquired tolerance to a wide range of antibiotics, thus causing severe illnesses and a tremendous economic impact in the healthcare sector. Due to its difficult treatment, knowledge...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2022-12, Vol.24 (6), Article 753
Main Authors: Gonzalez-Villarreal, Julia Alexsandra, Gonzalez-Lozano, Katia Jamileth, Arechiga-Carvajal, Elva Teresa, Morlett- Chavez, Jesus Antonio, Luevanos-Escareno, Miriam Paulina, Balagurusamy, Nagamani, Salinas-Santander, Mauricio Andres
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Bacteria
Drug resistance
Drug resistance in microorganisms
E coli
Evolution & development
Gastrointestinal diseases
Genetic aspects
Genetic engineering
Genetic research
Genetic transformation
Genomes
Infections
Microorganisms
Multidrug resistant organisms
Plasmids
Review
Virulence
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Summary:Multidrug resistant (MDR) enteropathogenic bacteria are a growing problem within the clinical environment due to their acquired tolerance to a wide range of antibiotics, thus causing severe illnesses and a tremendous economic impact in the healthcare sector. Due to its difficult treatment, knowledge and understanding of the molecular mechanisms that confer this resistance are needed. The aim of the present review is to describe the mechanisms of antibiotic resistance from a genomic perspective observed in bacteria, including naturally acquired resistance. The present review also discusses common pharmacological and alternative treatments used in cases of infection caused by MDR bacteria, thus covering necessary information for the development of novel antimicrobials and adjuvant molecules inhibiting bacterial proliferation.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2022.11689