New-onset Seropositive Rheumatoid Arthritis Following COVID-19 Vaccination in a Patient with Seronegative Status

Coronavirus disease 2019 (COVID-19) has spread worldwide since 2019, and mRNA vaccines for the disease have been rapidly delivered to limit the severity of infection. However, while these vaccines are effective in reducing the morbidity and severity of the disease, some patients develop severe adver...

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Bibliographic Details
Published in:Internal Medicine 2022/11/15, Vol.61(22), pp.3449-3452
Main Authors: Yonezawa, Haruka, Ohmura, Shin-ichiro, Ohkubo, Yusuke, Miyamoto, Toshiaki
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
autoimmune phenomena
Case Report
Case reports
Citrulline
Coronaviruses
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Heart diseases
Humans
Internal medicine
Morbidity
mRNA
mRNA vaccine
Myocarditis
Rheumatoid arthritis
Rheumatoid Factor
RNA, Messenger
seropositive
Thrombocytopenia
Thrombosis
Vaccination - adverse effects
Vaccines
Vasculitis
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Summary:Coronavirus disease 2019 (COVID-19) has spread worldwide since 2019, and mRNA vaccines for the disease have been rapidly delivered to limit the severity of infection. However, while these vaccines are effective in reducing the morbidity and severity of the disease, some patients develop severe adverse drug reactions and new-onset autoimmune phenomena, such as myocarditis, thrombosis with thrombocytopenia, and vasculitis. In addition, some patients develop arthritis following vaccination, including rheumatoid arthritis (RA). We herein report a case of new-onset seropositive RA following COVID-19 mRNA vaccination. Although tests for rheumatoid factor and anti-cyclic citrullinated peptide antibody had been negative three years before vaccination, the patient developed seropositive RA following COVID-19 mRNA vaccination.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.0257-22