om92 , a glp-1 enhancer mutation, is an allele of ekl-1

Germline stem cell proliferation in requires activation of the GLP-1/Notch receptor, which is located on the germline plasma membrane and encoded by the gene. We previously identified several genes whose products directly or indirectly promote activity of the GLP-1 signaling pathway by finding mutat...

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Bibliographic Details
Published in:microPublication biology 2022, Vol.2022
Main Authors: Stein, Samantha A, Zucaro, Olivia F, Smith, Harold E, O'Connell, Kevin F, Spoerke, Jill M, Maine, Eleanor M, Lissemore, James L
Format: Article
Language:English
Subjects:
C. Elegans
Genotype Data
New Finding
Phenotype Data
Online Access:Get full text
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Summary:Germline stem cell proliferation in requires activation of the GLP-1/Notch receptor, which is located on the germline plasma membrane and encoded by the gene. We previously identified several genes whose products directly or indirectly promote activity of the GLP-1 signaling pathway by finding mutations that enhance the germline phenotype of a allele, . Here, we report phenotypic and molecular analysis of a new allele, , that enhances the phenotype. is a 244 bp deletion predicted to generate a frameshift and premature termination codon, yielding a severely truncated protein, suggesting it is a null allele.
ISSN:2578-9430
DOI:10.17912/micropub.biology.000698