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om92 , a glp-1 enhancer mutation, is an allele of ekl-1
Germline stem cell proliferation in requires activation of the GLP-1/Notch receptor, which is located on the germline plasma membrane and encoded by the gene. We previously identified several genes whose products directly or indirectly promote activity of the GLP-1 signaling pathway by finding mutat...
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| Published in: | microPublication biology 2022, Vol.2022 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| container_title | microPublication biology |
| container_volume | 2022 |
| creator | Stein, Samantha A Zucaro, Olivia F Smith, Harold E O'Connell, Kevin F Spoerke, Jill M Maine, Eleanor M Lissemore, James L |
| description | Germline stem cell proliferation in
requires activation of the GLP-1/Notch receptor, which is located on the germline plasma membrane and encoded by the
gene. We previously identified several genes whose products directly or indirectly promote activity of the GLP-1 signaling pathway by finding mutations that enhance the germline phenotype of a
allele,
. Here, we report phenotypic and molecular analysis of a new
allele,
, that enhances the
phenotype.
is a 244 bp deletion predicted to generate a frameshift and premature termination codon, yielding a severely truncated protein, suggesting it is a null allele. |
| doi_str_mv | 10.17912/micropub.biology.000698 |
| format | article |
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requires activation of the GLP-1/Notch receptor, which is located on the germline plasma membrane and encoded by the
gene. We previously identified several genes whose products directly or indirectly promote activity of the GLP-1 signaling pathway by finding mutations that enhance the germline phenotype of a
allele,
. Here, we report phenotypic and molecular analysis of a new
allele,
, that enhances the
phenotype.
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requires activation of the GLP-1/Notch receptor, which is located on the germline plasma membrane and encoded by the
gene. We previously identified several genes whose products directly or indirectly promote activity of the GLP-1 signaling pathway by finding mutations that enhance the germline phenotype of a
allele,
. Here, we report phenotypic and molecular analysis of a new
allele,
, that enhances the
phenotype.
is a 244 bp deletion predicted to generate a frameshift and premature termination codon, yielding a severely truncated protein, suggesting it is a null allele.</description><subject>C. Elegans</subject><subject>Genotype Data</subject><subject>New Finding</subject><subject>Phenotype Data</subject><issn>2578-9430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVkEtLAzEUhYMgtmj_gmTpolOTzOS1EaT4goIbXYebmUwbzSR1MiP03ztgFV0d7j2X73APQpiSFZWasuvO133aj3ZlfQppe1gRQoRWJ2jOuFSFrkoyQ4uc36Y9o1RKys_QrBS8JJXkcyRTpxleYsDbsC8odnEHsXY97sYBBp_iEvuMIWIIwQWHU4vdeyjoBTptIWS3OOo5er2_e1k_Fpvnh6f17aZoqCC6sMRCAxUXTEtquVKqdNxqAmUr2qZVVsE0EFG31BLKgTHe0EqLxlakYqItz9HNN3f6sXNN7eLQQzD73nfQH0wCb_470e_MNn0aLbkgSk-AqyOgTx-jy4PpfK5dCBBdGrNhknNFOKNyOr38m_Ub8tNW-QUrbG1k</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Stein, Samantha A</creator><creator>Zucaro, Olivia F</creator><creator>Smith, Harold E</creator><creator>O'Connell, Kevin F</creator><creator>Spoerke, Jill M</creator><creator>Maine, Eleanor M</creator><creator>Lissemore, James L</creator><general>Caltech Library</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2022</creationdate><title>om92 , a glp-1 enhancer mutation, is an allele of ekl-1</title><author>Stein, Samantha A ; Zucaro, Olivia F ; Smith, Harold E ; O'Connell, Kevin F ; Spoerke, Jill M ; Maine, Eleanor M ; Lissemore, James L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d1609-b0bada4562971b58883e5b90a3f6fdf8b8a90a06cf1b015a225d1496db40426f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>C. Elegans</topic><topic>Genotype Data</topic><topic>New Finding</topic><topic>Phenotype Data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stein, Samantha A</creatorcontrib><creatorcontrib>Zucaro, Olivia F</creatorcontrib><creatorcontrib>Smith, Harold E</creatorcontrib><creatorcontrib>O'Connell, Kevin F</creatorcontrib><creatorcontrib>Spoerke, Jill M</creatorcontrib><creatorcontrib>Maine, Eleanor M</creatorcontrib><creatorcontrib>Lissemore, James L</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>microPublication biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stein, Samantha A</au><au>Zucaro, Olivia F</au><au>Smith, Harold E</au><au>O'Connell, Kevin F</au><au>Spoerke, Jill M</au><au>Maine, Eleanor M</au><au>Lissemore, James L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>om92 , a glp-1 enhancer mutation, is an allele of ekl-1</atitle><jtitle>microPublication biology</jtitle><addtitle>MicroPubl Biol</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><eissn>2578-9430</eissn><abstract>Germline stem cell proliferation in
requires activation of the GLP-1/Notch receptor, which is located on the germline plasma membrane and encoded by the
gene. We previously identified several genes whose products directly or indirectly promote activity of the GLP-1 signaling pathway by finding mutations that enhance the germline phenotype of a
allele,
. Here, we report phenotypic and molecular analysis of a new
allele,
, that enhances the
phenotype.
is a 244 bp deletion predicted to generate a frameshift and premature termination codon, yielding a severely truncated protein, suggesting it is a null allele.</abstract><cop>United States</cop><pub>Caltech Library</pub><pmid>36530475</pmid><doi>10.17912/micropub.biology.000698</doi><oa>free_for_read</oa></addata></record> |
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| identifier | EISSN: 2578-9430 |
| ispartof | microPublication biology, 2022, Vol.2022 |
| issn | 2578-9430 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9756089 |
| source | PubMed Central |
| subjects | C. Elegans Genotype Data New Finding Phenotype Data |
| title | om92 , a glp-1 enhancer mutation, is an allele of ekl-1 |
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