EVs vs. EVs: MSCs and Tregs as a source of invisible possibilities

Extracellular vesicles (EVs) are produced by various cells and exist in most biological fluids. They play an important role in cell–cell signaling, immune response, and tumor metastasis, and also have theranostic potential. They deliver many functional biomolecules, including DNA, microRNAs (miRNA),...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2023-02, Vol.101 (1-2), p.51-63
Main Authors: Heydari, Zahra, Peshkova, Maria, Gonen, Zeynep Burcin, Coretchi, Ianos, Eken, Ahmet, Yay, Arzu Hanım, Dogan, Muhammet Ensar, Gokce, Nuriye, Akalin, Hilal, Kosheleva, Nastasia, Galea-Abdusa, Daniela, Ulinici, Mariana, Vorojbit, Valentina, Shpichka, Anastasia, Groppa, Stanislav, Vosough, Massoud, Todiras, Mihail, Butnaru, Denis, Ozkul, Yusuf, Timashev, Peter
Format: Article
Language:English
Subjects:
Arthritis
Autoimmune diseases
Biomedical and Life Sciences
Biomedicine
Blood-brain barrier
Cancer
Cell signaling
Clinical trials
Cytokines
Extracellular vesicles
Extracellular Vesicles - metabolism
Growth factors
Human Genetics
Immune system
Immunogenicity
Immunology
Immunoregulation
Internal Medicine
Laboratories
Lipids
Lymphocytes
Lymphocytes T
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells - metabolism
Mesenchyme
Metastases
MicroRNAs
MicroRNAs - metabolism
miRNA
Molecular Medicine
mRNA
Neurosciences
Non-coding RNA
Pharmacy
Physiology
Proteins - metabolism
Regenerative medicine
Research centers
Respiratory distress syndrome
Review
Stem cells
Stromal cells
Transplants & implants
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Description
Summary:Extracellular vesicles (EVs) are produced by various cells and exist in most biological fluids. They play an important role in cell–cell signaling, immune response, and tumor metastasis, and also have theranostic potential. They deliver many functional biomolecules, including DNA, microRNAs (miRNA), messenger RNA (mRNA), long non-coding RNA (lncRNA), lipids, and proteins, thus affecting different physiological processes in target cells. Decreased immunogenicity compared to liposomes or viral vectors and the ability to cross through physiological barriers such as the blood–brain barrier make them an attractive and innovative option as diagnostic biomarkers and therapeutic carriers. Here, we highlighted two types of cells that can produce functional EVs, namely, mesenchymal stem/stromal cells (MSCs) and regulatory T cells (Tregs), discussing MSC/Treg-derived EV-based therapies for some specific diseases including acute respiratory distress syndrome (ARDS), autoimmune diseases, and cancer.
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-022-02276-2