Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers

Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exos...

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Bibliographic Details
Published in:International journal of biological sciences 2023, Vol.19 (1), p.167-182
Main Authors: Lu, Zeyi, Chen, Yuanlei, Luo, Wenqin, Ding, Lifeng, Wang, Huan, Li, Yang, Yang, Bo Wen, Ren, Liangliang, Zheng, Qiming, Xie, Haiyun, Wang, Ruyue, Yu, Chenhao, Lin, Yudong, Zhou, Zhenwei, Xia, Liqun, Li, Gonghui
Format: Article
Language:English
Subjects:
Androgens
Apoptosis
Biomarkers
Biomarkers, Tumor
Biopsy
Biosynthesis
Bladder
Cancer
Cancer therapies
Drug dosages
Drug resistance
Drug Resistance, Neoplasm - genetics
Endocrine therapy
Exosomes
Fibroblasts
Humans
Kidney cancer
Kinases
Liquid Biopsy
Medical prognosis
Metabolism
Metabolites
Metastasis
Mitochondrial DNA
Neoplasms - drug therapy
Physiology
Plasma
Prostate cancer
Proteins
Review
Tumors
Urogenital Neoplasms - pathology
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Summary:Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exosomes can modulate drug resistance via multiple mechanisms. This review attempts to elucidate the mechanisms of exosomal cargoes with reference to tumor drug resistance, their role in genitourinary cancers, and their potential clinical applications as candidate biomarkers in liquid biopsy.
ISSN:1449-2288
1449-2288
DOI:10.7150/ijbs.78321