Sodium Selenite As Potential Adjuvant Therapy for COVID-19

The review considers the role that selenium plays in RNA virus infections and, in particular, COVID-19. Many RNA viruses are selenium dependent because antisense interactions arise between viral RNAs and host mRNA regions containing the selencysteine insertion sequence to cause selenium deficiency,...

Full description

Saved in:
Bibliographic Details
Published in:Biophysics (Oxford) 2022, Vol.67 (5), p.775-778
Main Authors: Huseynov, T. M., Guliyeva, R. T., Jafarova, S. H., Jafar, N. H.
Format: Article
Language:English
Subjects:
Adjuvant therapy
Biological and Medical Physics
Biophysics
Cell Biophysics
Cell membranes
Coronaviruses
COVID-19
Immune response
mRNA
NF-κB protein
Oxidative stress
Physics
Physics and Astronomy
RNA viruses
Selenium
Severe acute respiratory syndrome coronavirus 2
Sodium selenite
Sulfur
Virions
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The review considers the role that selenium plays in RNA virus infections and, in particular, COVID-19. Many RNA viruses are selenium dependent because antisense interactions arise between viral RNAs and host mRNA regions containing the selencysteine insertion sequence to cause selenium deficiency, oxidative stress, immune response impairment, etc. Sodium selenite is a licensed selenium-containing product and is widely used in medicine, veterinary, and agriculture. Its advantages include the following. Sodium selenite rapidly penetrates through cell membranes in all tissues of the body; is intensely involved in metabolic processes accompanied by oxidation of sulfur-containing cell proteins; exerts an antiaggregation effect by reducing thromboxane activity; interrupts the contact of a virion (SARS-CoV-1 and SARS-CoV-2) with the membrane of a healthy cell; and suppresses NF-κB activity, which significantly increases in coronavirus infections. Arguments supporting the use of sodium selenite as adjuvant therapy in COVID-19 are discussed.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350922050074