A functional cra gene is required for Salmonella enterica serovar Typhimurium virulence in BALB/c mice

A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad(-), is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129-134, 1998). Here, ev...

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Bibliographic Details
Published in:Infection and immunity 2000-06, Vol.68 (6), p.3772-3775
Main Authors: ALLEN, J. H, UTLEY, M, LEATHAM, M. P, LAUX, D. C, COHEN, P. S, VAN DEN BOSCH, H, NUIJTEN, P, WITVLIET, M, MCCORMICK, B. A, KROGFELT, K. A, LICHT, T. R, BROWN, D, MAUEL, M
Format: Article
Language:English
Subjects:
Animals
Bacterial Proteins - genetics
Bacteriology
Biological and medical sciences
Carbohydrate Metabolism
Citric Acid Cycle
cra gene
Cra protein
Fundamental and applied biological sciences. Psychology
Genes, Bacterial
Genetics
Intestines - microbiology
Macrophages, Peritoneal - microbiology
Mice
Mice, Inbred BALB C
Microbiology
Molecular and Cellular Pathogenesis
Mucus - microbiology
Mutagenesis, Insertional
Repressor Proteins - genetics
Salmonella enterica
Salmonella typhimurium - genetics
Salmonella typhimurium - metabolism
Salmonella typhimurium - pathogenicity
Serotyping
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Summary:A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad(-), is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129-134, 1998). Here, evidence is presented that the mutation in SR-11 Fad(-) that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.68.6.3772-3775.2000