Allicin-Loaded Hydroxyapatite: Enhanced Release, Cytocompatibility, and Antibacterial Properties for Bone Tissue Engineering Applications

Allicin, the active compound of garlic extract, is a naturally sourced biomolecule, which promotes a vast range of health benefits. However, the limited stability of allicin restricts its applications in tissue engineering. Additionally, the detailed effects of allicin in bone health are yet to be e...

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Bibliographic Details
Published in:JOM (1989) 2022-09, Vol.74 (9), p.3349-3356
Main Authors: Bose, Susmita, Bhattacharjee, Arjak, Huynh, Christine, Banerjee, Dishary
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Bacterial infections
Biocompatibility
Biological properties
Biomedical materials
Biomolecules
Bone diseases
Chemistry/Food Science
Drug delivery systems
Earth Sciences
Efficiency
Electron microscopes
Engineering
Environment
Fourier transforms
Garlic
Hydroxyapatite
Interactions between Biomaterials and Biological Tissues and Cells
Lasers
Microscopy
Physics
Physiology
Polycaprolactone
Scaffolds
Skin & tissue grafts
Stability
Tissue engineering
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Summary:Allicin, the active compound of garlic extract, is a naturally sourced biomolecule, which promotes a vast range of health benefits. However, the limited stability of allicin restricts its applications in tissue engineering. Additionally, the detailed effects of allicin in bone health are yet to be explored. Our work reports on the fabrication of a novel allicin-loaded hydroxyapatite drug delivery system with enhanced biological properties. The fabricated system shows excellent antibacterial efficiency against S. aureus after 36 h of bacterial interaction with a sample. The allicin release kinetics are enhanced with polycaprolactone (PCL). The obtained results after 20 days of drug release study indicate that PCL coating leads to an increase in cumulative allicin release from ~ 35% to 70% at a physiological pH of 7.4. These scaffolds maintain stability during the whole period of drug release. Cytocompatibility of tested compositions with osteoblasts indicates enhanced cell viability and good filopodial attachment on the sample surface at day 7. These allicin-loaded antibacterial and cytocompatible scaffolds can find applications as localized delivery vehicles for bone tissue engineering.
ISSN:1047-4838
1543-1851
DOI:10.1007/s11837-022-05366-1