Solitary fibrous tumor of male breast: A case report and literature review

Solitary fibrous tumors (SFT) are uncommon mesenchymal neoplasms which can arise in any anatomical location. Pleural SFTs have been most frequently documented; however, breast SFT is an exceedingly rare entity and seldom present in male breast, with only 8 previously reported cases. Recently, STAT6...

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Published in:Medicine (Baltimore) 2022-12, Vol.101 (50), p.e32199-e32199
Main Authors: Kawaguchi, Shun, Kinowaki, Keiichi, Tamura, Nobuko, Nishikawa, Aya, Shibata, Akio, Tanaka, Kiyo, Kobayashi, Yoko, Ogura, Takuya, Sato, Junichiro, Kawabata, Hidetaka
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor
Breast - pathology
Clinical Case Report
Hemangiopericytoma - pathology
Humans
Male
Severe Fever with Thrombocytopenia Syndrome
Solitary Fibrous Tumors - diagnostic imaging
Solitary Fibrous Tumors - surgery
Ultrasonography
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Summary:Solitary fibrous tumors (SFT) are uncommon mesenchymal neoplasms which can arise in any anatomical location. Pleural SFTs have been most frequently documented; however, breast SFT is an exceedingly rare entity and seldom present in male breast, with only 8 previously reported cases. Recently, STAT6 immunostaining was considered to be a definitive marker of SFT, however, no case of the male breast SFT showing STAT6 positivity preoperatively has been reported. We describe a case of breast SFT in a 73-year-old male patient with a 12-month history of a palpable breast mass. The only associated clinical symptom was bilateral gynecomastia. An ultrasound scan examination revealed an oval, well-circumscribed and hypoechoic mass with hypervascularity. A core-needle biopsy was performed, and microscopic examination with immunohistochemistry confirmed the diagnosis of SFT. He underwent a complete surgical resection with clear margins, and there were no signs of high cellularity, remarkable mitotic activity, pleomorphism, hemorrhage or necrosis. A perioperative immunohistochemical evaluation for diffuse and intense nuclear expression of STAT6 was helpful to distinguish SFT from myofibroblastoma. We, herein, describe the first case of SFT in a male breast, confirmed by STAT6 immunostaining positivity. We also conducted a literature review of all previous cases of breast SFTs.
ISSN:1536-5964
0025-7974
1536-5964
DOI:10.1097/MD.0000000000032199