Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study

• Published in: International journal of environmental research and public health 2022-12, Vol.19 (24), p.16608
• Main Authors: Landeros, Natalia, Duk, Soledad, Márquez, Carolina, Inzunza, Bárbara, Acuña-Rodríguez, Ian S, Zúñiga-Venegas, Liliana A
• Format: Article
• Language: English
• Subjects: Agricultural production; Agriculture; Agrochemicals; Biomarkers; Chile - epidemiology; Chronic exposure; Chronic illnesses; Climate change; Congenital diseases; DNA Damage; Epidemiology; Exposure; Factor analysis; Farmworkers; Female; Genotoxicity; Health risks; Humans; Infertility; Lymphocytes; Micronuclei; Miscarriage; Occupational exposure; Occupational Exposure - adverse effects; Occupational Exposure - analysis; Ordination; Pesticides; Pesticides - analysis; Pesticides - toxicity; Pilot Projects; Poisoning; Population; Reproductive health; Risk; Rural areas; Urban areas; Womens health
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph192416608

Significant risks to human health have been associated with chronic exposure to low doses of pesticides, a situation which may be frequent among agricultural workers. In this context, and regarding the agricultural-based economy of central Chile, we aimed to explore the genotoxic damage in agricultural workers and reproductive risk among women in rural and urban areas of Curicó, a traditional agricultural district in Chile. Hence, we sampled a group of rural agricultural workers associated with pesticide management ( = 30) and an urban unexposed group ( = 30). Our results showed that the agricultural workers had higher micronuclei frequencies (MN: β = 13.27; 95% CI = 11.08, CI = 15.47) and women had a 40-fold higher risk of reproductive problems (OR = 40.32; 95% CI = 2.60, CI = 624.31) than the unexposed group. The factor analysis of mixed data (FAMD) showed that neither the sex nor smoking habits appear to define the ordination of the data. Nevertheless, the exposure level did segregate them in the multidimensional space (explained variance: 35.38% dim-1; 18.63% dim-2). This pilot study highlights the higher risks of biological conditions negatively associated with the health of agricultural workers.